Polypill Strategy in Secondary Cardiovascular Prevention

Among patients with recent MI, therapy with a polypill containing aspirin, ramipril, and atorvastatin led to a lower incidence of major adverse cardiovascular events at a median of 3 years than usual care.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2022-09, Vol.387 (11), p.967-977
Hauptverfasser:	Castellano, Jose M., Pocock, Stuart J., Bhatt, Deepak L., Quesada, Antonio J., Owen, Ruth, Fernandez-Ortiz, Antonio, Sanchez, Pedro L., Marin Ortuño, Francisco, Vazquez Rodriguez, Jose M., Domingo-Fernández, Alexandra, Lozano, Iñigo, Roncaglioni, Maria C., Baviera, Marta, Foresta, Andreana, Ojeda-Fernandez, Luisa, Colivicchi, Furio, Di Fusco, Stefania A., Doehner, Wolfram, Meyer, Antje, Schiele, François, Ecarnot, Fiona, Linhart, Aleš, Lubanda, Jean-Claude, Barczi, Gyorgy, Merkely, Bela, Ponikowski, Piotr, Kasprzak, Marta, Fernandez Alvira, Juan M., Andres, Vicente, Bueno, Hector, Collier, Timothy, Van de Werf, Frans, Perel, Pablo, Rodriguez-Manero, Moises, Alonso Garcia, Angeles, Proietti, Marco, Schoos, Mikkel M., Simon, Tabassome, Fernandez Ferro, Jose, Lopez, Nicolas, Beghi, Ettore, Bejot, Yannick, Vivas, David, Cordero, Alberto, Ibañez, Borja, Fuster, Valentin
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Angiotensin-Converting Enzyme Inhibitors - adverse effects Angiotensin-Converting Enzyme Inhibitors - therapeutic use Aspirin Aspirin - adverse effects Aspirin - therapeutic use Atorvastatin Atorvastatin - adverse effects Atorvastatin - therapeutic use Blood pressure Cardiology Cardiology General Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - etiology Cardiovascular Diseases - mortality Cardiovascular Diseases - prevention & control Cerebral infarction Clinical Medicine Confidence intervals Coronary Disease Death Diabetes Disease prevention Drug dosages Heart attacks Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Ischemia Ischemic Stroke - prevention & control Myocardial Infarction Myocardial Infarction - complications Myocardial Infarction - prevention & control Myocardial Infarction - therapy Outpatient-Based Clinical Medicine Patient compliance Patients Platelet Aggregation Inhibitors - adverse effects Platelet Aggregation Inhibitors - therapeutic use Polypharmacy Prevention Ramipril - adverse effects Ramipril - therapeutic use Secondary Prevention - methods Stroke
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Beschreibung
Zusammenfassung:	Among patients with recent MI, therapy with a polypill containing aspirin, ramipril, and atorvastatin led to a lower incidence of major adverse cardiovascular events at a median of 3 years than usual care.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2208275