Study of Microcirculation and Blood Rheology in Persons with Different Levels of Maximum Oxygen Consumption

Oxygen delivery to cellular microdistricts is ensured by the coordinated work of systemic hemodynamics, microcirculation, and effective blood flow. However, the contribution of each link of this functional system with different oxygen supply to the body is insufficiently studied. The aim of the study was to conduct a comparative analysis of a set of indicators related to different levels of integration of the circulatory system in individuals with different levels of maximum oxygen consumption. Using the methods of viscometry, aggregatometry, and evaluation of the deformability of erythrocytes, the features of the hemorheological profile of individuals with different aerobic potential were determined. The registration of microcirculation parameters using biomicroscopy and laser Doppler imaging at rest and under conditions of intensive muscle work allowed us to obtain data on the state of microvessels and skin perfusion, as well as on the reserves of cutaneous blood flow in individuals with different levels of maximum oxygen consumption. The results indicate that high aerobic potential is combined with economical functioning of the circulatory system at rest not only at the level of macro-, but also microcirculation. Individuals with higher maximum oxygen consumption are characterized by increased reserves of microvascular perfusion, which are achieved due to a larger capillary diameter and moderately reduced blood viscosity.