IDDF2022-ABS-0122 Preoperative quality of life and mental health can predict postoperative outcomes and quality of life after colorectal cancer surgery

BackgroundPreoperative health-related quality of life (HRQOL), including anxiety and depression, provides prognostic information on survival and postoperative mortality in colorectal cancer (CRC) patients. However, it is uncertain if preoperative HRQOL can predict postoperative clinical and patient-reported outcomes.MethodsA prospective cohort of 78 CRC patients undergoing elective curative surgery was recruited. European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (QLQ-C30) and Hospital Anxiety and Depression Scale (HADS) were administered preoperatively and one month after surgery.ResultsPreoperative cognitive functioning scores (95% CI 0.131 – 1.158, p = 0.015) and low anterior resection (95% CI 14.861 – 63.260, p = 0.002) independently predicted for poorer 1-month postoperative global QOL (IDDF2022-ABS-0122 Table 1). The overall regression was statistically significant (R2: 0.546, F: 1.961, p = 0.023). Associations between preoperative European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (QLQ-C30)/Hospital Anxiety and Depression Scale (HADS) mean scores and postoperative outcomes are illustrated in IDDF2022-ABS-0122 Table 2. When postoperative complications were represented using the comprehensive complication index (CCI), poorer preoperative physical function scores were associated with higher CCI scores (B = -0.277, p = 0.014), though the overall regression model was not statistically significant (R2: 0.134, F: 1.320, p = 0.249). Preoperative social function score (OR = 0.925, 95% CI 0.87 to 0.99; p = 0.019) was an independent predictor for postoperative readmission, while physical functioning score (OR = -0.620, 95% CI -1.073 – -0.167, p = 0.008) was inversely related to the length of hospitalization. The overall regressions for readmission (R2: 0.322, χ2: 13.129, p < 0.001) and length of hospitalization (R2: 0.156, F: 1.577, p = 0.148) were statistically significant.Abstract IDDF2022-ABS-0122 Table 1Univariate and multivariate analyses for predictors of 1 month postoperative global QOL Univariate analysis Multivariate analysis (R2.0.546, F: 1.961, p = 0.023) Factor p-value B 95% CI p-value EORTC QLQ-C30 Global QOL 0.037 0.129 -0.136 – 0.394 0.332 Physical functioning 0.158 0.015 -0.493 – 0.522 0.954 Role functioning 0.780 0.153 -0.313 – 0.619 0.512 Emotional functioning 0.010 0.183 -0.163 – 0.529 0.291 Cognitive functioning 0.010 0.645 0.131 – 1.158 0.015 Social functioning 0.1