Overweight and obese poorly controlled severe asthma patients have increased levels of gut permeability biomarkers lipopolysaccharide-binding protein (LBP) and calprotectin

Descriptive statistics, group comparisons with one-way-ANOVA (AN), Kruskal-Wallis (KW) or Mann Whitney (MW) tests and simple linear regression test were conducted to compare the association between BMI, ACQ-6 score and gut permeability markers. In summary, increased levels of gut permeability markers were associated with poorer asthma control, increased body weight, and increasing inflammatory markers of asthma. Furthermore, the role of these intestinal permeability markers suggests that the intestinal barrier could be the target of future dietary interventions to improve disease management.