A Procedure for Preparing Effective Immunomodulators and Antioxidants: 5-Hydroxy-6-methyluracil and 5-Hydroxy-1,3,6-trimethyluracil
5-Hydroxy-6-methyluracil is an acting agent of Oxymethyluracilum drug, an immunostimulator with a broad spectrum of pharmacological activity. Its synthesis is based on the 6-methyluracil oxidation with (NH 4 ) 2 S 2 O 8 under the conditions of Elbs reaction. The Elbs oxidation of 6-methyluracil in t...
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| Veröffentlicht in: | Russian journal of applied chemistry 2022-03, Vol.95 (3), p.436-441 |
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| container_title | Russian journal of applied chemistry |
| container_volume | 95 |
| creator | Gimadieva, A. R. Khazimullina, Yu. Z. Abdrakhmanov, I. B. Mustafin, A. G. |
| description | 5-Hydroxy-6-methyluracil is an acting agent of Oxymethyluracilum drug, an immunostimulator with a broad spectrum of pharmacological activity. Its synthesis is based on the 6-methyluracil oxidation with (NH
4
)
2
S
2
O
8
under the conditions of Elbs reaction. The Elbs oxidation of 6-methyluracil in the presence of metal phthalocyanine oxidation catalysts was studied. Conditions allowing the 5-hydroxy-6-methyluracil yield to be increased to 95% were found. The most active catalysts are Fe(II), Fe(III), and Co phthalocyanines. |
| doi_str_mv | 10.1134/S1070427222030144 |
| format | Article |
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4
)
2
S
2
O
8
under the conditions of Elbs reaction. The Elbs oxidation of 6-methyluracil in the presence of metal phthalocyanine oxidation catalysts was studied. Conditions allowing the 5-hydroxy-6-methyluracil yield to be increased to 95% were found. The most active catalysts are Fe(II), Fe(III), and Co phthalocyanines.</description><identifier>ISSN: 1070-4272</identifier><identifier>EISSN: 1608-3296</identifier><identifier>DOI: 10.1134/S1070427222030144</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Catalysts ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Immunomodulators ; Industrial Chemistry/Chemical Engineering ; Metal phthalocyanines ; Organic Synthesis and Industrial Organic Chemistry ; Oxidation</subject><ispartof>Russian journal of applied chemistry, 2022-03, Vol.95 (3), p.436-441</ispartof><rights>Pleiades Publishing, Ltd. 2022</rights><rights>Pleiades Publishing, Ltd. 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c246t-e6cbc0509b284279d2cb277d33f9d9b65870cd1e6ed9d5dee4dd4475527bec293</citedby><cites>FETCH-LOGICAL-c246t-e6cbc0509b284279d2cb277d33f9d9b65870cd1e6ed9d5dee4dd4475527bec293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1070427222030144$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1070427222030144$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Gimadieva, A. R.</creatorcontrib><creatorcontrib>Khazimullina, Yu. Z.</creatorcontrib><creatorcontrib>Abdrakhmanov, I. B.</creatorcontrib><creatorcontrib>Mustafin, A. G.</creatorcontrib><title>A Procedure for Preparing Effective Immunomodulators and Antioxidants: 5-Hydroxy-6-methyluracil and 5-Hydroxy-1,3,6-trimethyluracil</title><title>Russian journal of applied chemistry</title><addtitle>Russ J Appl Chem</addtitle><description>5-Hydroxy-6-methyluracil is an acting agent of Oxymethyluracilum drug, an immunostimulator with a broad spectrum of pharmacological activity. Its synthesis is based on the 6-methyluracil oxidation with (NH
4
)
2
S
2
O
8
under the conditions of Elbs reaction. The Elbs oxidation of 6-methyluracil in the presence of metal phthalocyanine oxidation catalysts was studied. Conditions allowing the 5-hydroxy-6-methyluracil yield to be increased to 95% were found. The most active catalysts are Fe(II), Fe(III), and Co phthalocyanines.</description><subject>Catalysts</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Immunomodulators</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Metal phthalocyanines</subject><subject>Organic Synthesis and Industrial Organic Chemistry</subject><subject>Oxidation</subject><issn>1070-4272</issn><issn>1608-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1UFtLwzAUDqLgnP4A3wq-Lppbk8a3MaYbDBTU59ImqXa0zUxSWZ_942ZOmCA-nXP4LuecD4BLjK4xpuzmCSOBGBGEEEQRZuwIjDBHGaRE8uPYRxju8FNw5v0aISQ5z0bgc5o8OquM7p1JKuviZDaFq7vXZF5VRoX6wyTLtu0721rdN0WwzidFp5NpF2q7rXXRBX-bpHAxaGe3A-SwNeFtaHpXqLr5ph5APKETDoOrf3POwUlVNN5c_NQxeLmbP88WcPVwv5xNV1ARxgM0XJUKpUiWJIufSE1USYTQlFZSy5KnmUBKY8ONljrVxjCtGRNpSkRpFJF0DK72vhtn33vjQ762veviypwIFKMTlPHIwnuWctZ7Z6p8E88t3JBjlO-yzv9kHTVkr_GbXXTGHZz_F30BoUqBjQ</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Gimadieva, A. R.</creator><creator>Khazimullina, Yu. Z.</creator><creator>Abdrakhmanov, I. B.</creator><creator>Mustafin, A. G.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20220301</creationdate><title>A Procedure for Preparing Effective Immunomodulators and Antioxidants: 5-Hydroxy-6-methyluracil and 5-Hydroxy-1,3,6-trimethyluracil</title><author>Gimadieva, A. R. ; Khazimullina, Yu. Z. ; Abdrakhmanov, I. B. ; Mustafin, A. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c246t-e6cbc0509b284279d2cb277d33f9d9b65870cd1e6ed9d5dee4dd4475527bec293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Catalysts</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Immunomodulators</topic><topic>Industrial Chemistry/Chemical Engineering</topic><topic>Metal phthalocyanines</topic><topic>Organic Synthesis and Industrial Organic Chemistry</topic><topic>Oxidation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gimadieva, A. R.</creatorcontrib><creatorcontrib>Khazimullina, Yu. Z.</creatorcontrib><creatorcontrib>Abdrakhmanov, I. B.</creatorcontrib><creatorcontrib>Mustafin, A. G.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian journal of applied chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gimadieva, A. R.</au><au>Khazimullina, Yu. Z.</au><au>Abdrakhmanov, I. B.</au><au>Mustafin, A. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Procedure for Preparing Effective Immunomodulators and Antioxidants: 5-Hydroxy-6-methyluracil and 5-Hydroxy-1,3,6-trimethyluracil</atitle><jtitle>Russian journal of applied chemistry</jtitle><stitle>Russ J Appl Chem</stitle><date>2022-03-01</date><risdate>2022</risdate><volume>95</volume><issue>3</issue><spage>436</spage><epage>441</epage><pages>436-441</pages><issn>1070-4272</issn><eissn>1608-3296</eissn><abstract>5-Hydroxy-6-methyluracil is an acting agent of Oxymethyluracilum drug, an immunostimulator with a broad spectrum of pharmacological activity. Its synthesis is based on the 6-methyluracil oxidation with (NH
4
)
2
S
2
O
8
under the conditions of Elbs reaction. The Elbs oxidation of 6-methyluracil in the presence of metal phthalocyanine oxidation catalysts was studied. Conditions allowing the 5-hydroxy-6-methyluracil yield to be increased to 95% were found. The most active catalysts are Fe(II), Fe(III), and Co phthalocyanines.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1070427222030144</doi><tpages>6</tpages></addata></record> |
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| language | eng |
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| subjects | Catalysts Chemistry Chemistry and Materials Science Chemistry/Food Science Immunomodulators Industrial Chemistry/Chemical Engineering Metal phthalocyanines Organic Synthesis and Industrial Organic Chemistry Oxidation |
| title | A Procedure for Preparing Effective Immunomodulators and Antioxidants: 5-Hydroxy-6-methyluracil and 5-Hydroxy-1,3,6-trimethyluracil |
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