Endemic Mycoses and COVID-19: a Review

Purpose of Review SARS-CoV-2 generates an atypical pneumonia with high morbidity and mortality. In many cases, the torpid evolution was related to bacterial or fungal co-infections. Non-specific manifestations of COVID-19 infection can make the differential diagnosis with other systemic diseases even more difficult. A review of systemic endemic mycoses associated with COVID-19 was carried out. We will describe epidemiological data, clinical characteristics of the endemic mycosis, and different diagnostic resources. Recent Findings Database search process in PubMed, Latindex, and other online web was performed. From 78 published cases, coccidioidomycosis was the most frequent association followed in second place by histoplasmosis. Highly variable diagnostic methodologies were used, but all were useful. Summary Mortality caused by these endemic mycoses does not seem to have been modified by COVID-19.