First synthesis of an ABCE ring substructure of daphnicyclidin A

First synthesis of an ABCE ring substructure of daphnicyclidin A

The ABCE tetracyclic ring system of daphnicyclidin A was prepared using an intramolecular (4 + 3) cycloaddition of an oxidopyridinium ion as the key step. This route consists of a 10-step synthesis with an overall yield of 20.2%. This result offers support for the use of this strategy for total synt...

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Veröffentlicht in:Organic & biomolecular chemistry 2022-08, Vol.2 (33), p.6547-6549
Hauptverfasser: Tu, Jianzhuo, Clark, Madison M, Harmata, Michael
Format: Artikel
Sprache:eng
Schlagworte:
Cycloaddition
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Zusammenfassung:The ABCE tetracyclic ring system of daphnicyclidin A was prepared using an intramolecular (4 + 3) cycloaddition of an oxidopyridinium ion as the key step. This route consists of a 10-step synthesis with an overall yield of 20.2%. This result offers support for the use of this strategy for total synthesis of daphnicyclidin A. The ABCE tetracyclic ring system of daphnicyclidin A was prepared using an intramolecular (4 + 3) cycloaddition of an oxidopyridinium ion as the key step.
ISSN:1477-0520
1477-0539
DOI:10.1039/d2ob01246d