Synthesis, structural characterization and anticancer properties of p-cymene Ru(II) complexes with 2-(N-methyl-1H-1,2,4-triazol-3-yl)pyridines

Synthesis, structural characterization and anticancer properties of p-cymene Ru(II) complexes with 2-(N-methyl-1H-1,2,4-triazol-3-yl)pyridines

The structures of new p -cymene Ru(II) complexes with 2-(1-methyl-1H-1,2,4-triazol-3-yl)pyridine and 2-(1-methyl-1H-1,2,4-triazol-5-yl)pyridine were established based on the results of elemental analysis; IR and NMR spectra; and X-ray diffraction studies. Their anticancer activity, tested on human o...

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Veröffentlicht in:Transition metal chemistry (Weinheim) 2022-08, Vol.47 (6), p.213-221
Hauptverfasser: Ohorodnik, Yulia M., Alexander, Sikalov A., Khomenko, Dmytro M., Doroshchuk, Roman O., Raspertova, Ilona V., Shova, Sergiu, Babak, Maria V., Lampeka, Rostyslav D.
Format: Artikel
Sprache:eng
Schlagworte:
Anticancer properties
Catalysis
Chemical analysis
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
NMR
Nuclear magnetic resonance
Organometallic Chemistry
Physical Chemistry
Pyridines
Structural analysis
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Zusammenfassung:The structures of new p -cymene Ru(II) complexes with 2-(1-methyl-1H-1,2,4-triazol-3-yl)pyridine and 2-(1-methyl-1H-1,2,4-triazol-5-yl)pyridine were established based on the results of elemental analysis; IR and NMR spectra; and X-ray diffraction studies. Their anticancer activity, tested on human ovarian cancer cell lines A2780 (cisplatin-sensitive) and A2780cis (cisplatin-resistant), is also reported. Graphical abstract
ISSN:0340-4285
1572-901X
DOI:10.1007/s11243-022-00503-w