Access to cyclopentenones via copper-catalyzed 5- endo trifluoromethylcarbocyclization of ynones

A Cu-catalyzed 5- endo -selective trifluoromethylcarbocyclization of ynones is developed for the concise synthesis of trifluoromethylated cyclopentenones. The pivotal roles of carbonyl groups are well illustrated by experiments and density functional theory calculations.

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Bibliographische Detailangaben
Veröffentlicht in:	Organic Chemistry Frontiers 2022-08, Vol.9 (17), p.4670-4675
Hauptverfasser:	Le, Siya, Bai, Yihui, Qiu, Jiayan, Zhang, Zuxiao, Zheng, Hanliang, Zhu, Gangguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbonyl compounds Carbonyl groups Carbonyls Copper Density functional theory Organic chemistry
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	A Cu-catalyzed 5- endo -selective trifluoromethylcarbocyclization of ynones is developed for the concise synthesis of trifluoromethylated cyclopentenones. The pivotal roles of carbonyl groups are well illustrated by experiments and density functional theory calculations.
ISSN:	2052-4129 2052-4110 2052-4129 2052-4110
DOI:	10.1039/D2QO00843B