Acute cytomegalovirus infection in a 61-yearold woman

Cytomegalovirus (CMV) infection can vary from asymptomatic infection to tissue-invasive disease. Clinicians should recognize the difference between CMV infection and CMV disease: the former refers to evidence of CMV replication regardless of symptoms, while the latter refers to evidence of CMV infection with attributable symptoms. Furthermore, CMV disease can be categorized as a viral syndrome or tissue-invasive disease. Tissue-invasive disease is defined as appropriate clinical symptoms and signs of end-organ disease with documentation of CMV in tissue from the relevant organ. Here, Hongo et al examine the case of a 61-year-old woman with CMV infection.