Matteson Homologation of Arylboronic Esters

Commercially available arylboronic acids can easily be converted into chiral boronic esters which can be subjected to Matteson homologations using Grignard reagents. The best results are obtained in one pot protocols without isolation of the α‐chloroboronic ester intermediates. Alkoxides can also be used as nucleophiles, but the corresponding homologated boronic esters are found to be not stable. Under optimized conditions, chiral esters of commercially available arylboronic acids can be subjected to Matteson homologations in a one‐pot protocol using Grignard reagents without significant side reactions.