Orthogonally Protected, Carboxy-Activated L-Homoisoserine, 2-Methyl-L-homoisoserine, and Homoisocysteine Derivatives. New Building Blocks for Peptide and Depsipeptide Modification
Starting from L-malic, L-citramalic, and rac. thiomalic acids routes to L-homoisoserine, 2-methyl-L-homoisoserine and rac. homoisocysteine have been developed. The new orthogonally protected and carboxy-activated building blocks are GABA as well as α-hydroxy and α-mercapto acid derivatives, suitable...
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Veröffentlicht in: | Monatshefte für Chemie 2005-05, Vol.136 (5), p.763-776 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | Starting from L-malic, L-citramalic, and rac. thiomalic acids routes to L-homoisoserine, 2-methyl-L-homoisoserine and rac. homoisocysteine have been developed. The new orthogonally protected and carboxy-activated building blocks are GABA as well as α-hydroxy and α-mercapto acid derivatives, suitable for the construction of peptide and depsipeptide surrogates. |
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ISSN: | 0026-9247 1434-4475 |
DOI: | 10.1007/s00706-005-0291-1 |