Biogenic gold nanoparticles as antibrain cancer agents

This study aimed to look for economical and available plant sources whose pure extractors which are used in the biosynthesis of nanoparticles have inhibitory and toxic effectiveness and potency on brain cancer cells, and to study the ability of Grape Vitis Vinifera L seed effect on the cell line (A172) for brain cancer and cell line WRL68 for normal cells. It was prepared gold Nanoparticles by adding Gallic Acid (GA-GNPS) extracted from grape seeds to (HAuCL4.3H20). This work proved the capability of plant mediated nanoparticles production firstly by color change of the extract, then the well dispersed spherical with size 62 nm was proved by using techniques; ultra violet-visible spectroscopy (UV-vis), X-ray diffraction (XRD) and scanning electronic microscope (SEM) coupled with energy dispersion x-ray (EDX). The study report that GA-GNPS has inhibitory effectiveness leading the cell towards the primed death by testing the cellular toxicity, the results stated that GA-GNPS has inhibitory effectiveness on the cancer cell line cells (A172) where the highest inhibition value to grow the cell was (%61,27) upon the concentrations (400 µg/ml) and less value of inhabitation was (%4.36) upon the concentrations (25µg/ml) this is comparing with the natural cells, for cancer cells reached (IC50 46.99) while for natural cells reached (IC50 432.1) and testing the impacts which could happen in some of the cellular indications (HCS) including nuclear, cell count, intensity cell permeability, mitochondrial membrane potential and cytochrome. It was found during the study that (GA-GNPS) has obvious impact on the cellular properties upon the higher concentrations while its impact is little and decrease upon the minimum concentrations. The findings explained that there is an impact upon the concentrations (100&200µg/ml) on all cellular indications with moral differential (p