Transformation from lung adenocarcinoma to combined small cell carcinoma in pleural effusion after treatment with osimertinib

Transformation from lung adenocarcinoma to combined small cell carcinoma in pleural effusion after treatment with osimertinib

The transformation of lung adenocarcinoma to combined small cell lung cancer is a rare mechanism of acquired resistance to EGFR tyrosine kinase inhibitors. This case describes this mechanism in a pleural effusion of a young patient treated with osimertinib for 18 months.

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Veröffentlicht in:CYTOPATHOLOGY 2022-09, Vol.33 (5), p.633-635
Hauptverfasser: Frankel, Diane, Kaspi, Elise, Liprandi, Agnès, Dales, Jean‐Philippe, Roll, Patrice
Format: Artikel
Sprache:eng
Schlagworte:
Adenocarcinoma
combined small cell lung cancer
Genetics
Life Sciences
lung adenocarcinoma
osimertinib
Pleural effusion
Protein-tyrosine kinase
Small cell lung carcinoma
transformation
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Zusammenfassung:The transformation of lung adenocarcinoma to combined small cell lung cancer is a rare mechanism of acquired resistance to EGFR tyrosine kinase inhibitors. This case describes this mechanism in a pleural effusion of a young patient treated with osimertinib for 18 months.
ISSN:0956-5507
1365-2303
DOI:10.1111/cyt.13156