Multilayer nanostructured system for oral insulin delivery
A method to obtain a multilayer insulin-containing composition in a nanostructured form consisting of layers: gold-chitosan-insulin-chitosan nanoparticles was developed. The size of the fully formed multicomponent system was 178 nm.The outer layer of chitosan protects insulin from the damaging effec...
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| Veröffentlicht in: | Journal of polymer research 2022-09, Vol.29 (9), Article 378 |
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| container_title | Journal of polymer research |
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| creator | Apryatina, Kristina V. Glazova, Irina A. Koryagin, Alexander S. Zaitsev, Sergey D. Smirnova, Larisa A. |
| description | A method to obtain a multilayer insulin-containing composition in a nanostructured form consisting of layers: gold-chitosan-insulin-chitosan nanoparticles was developed. The size of the fully formed multicomponent system was 178 nm.The outer layer of chitosan protects insulin from the damaging effects of low pH-medium and proteolytic enzymes of the gastrointestinal tract when the composition is taken orally. Chitosan simultaneously performs a transport function to deliver insulin into the bloodstream. In experiments on experimental animals with artificially induced type 1 diabetes, it was found that the effectiveness and duration of hypoglycemic action of the composition depends on the amount of insulin in the dose. The composition containing 50 IU of insulin per dose provides a rapid decrease glucose level in the blood and maintains it at the level of the intact group for 3 h. After 6 h the efficacy of the composition is comparable to that of insulin injection. A fundamentally important indicator of the effectiveness of the composition is a constant content of glycated hemoglobin in the blood within 10 days. |
| doi_str_mv | 10.1007/s10965-022-03225-w |
| format | Article |
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The size of the fully formed multicomponent system was 178 nm.The outer layer of chitosan protects insulin from the damaging effects of low pH-medium and proteolytic enzymes of the gastrointestinal tract when the composition is taken orally. Chitosan simultaneously performs a transport function to deliver insulin into the bloodstream. In experiments on experimental animals with artificially induced type 1 diabetes, it was found that the effectiveness and duration of hypoglycemic action of the composition depends on the amount of insulin in the dose. The composition containing 50 IU of insulin per dose provides a rapid decrease glucose level in the blood and maintains it at the level of the intact group for 3 h. After 6 h the efficacy of the composition is comparable to that of insulin injection. A fundamentally important indicator of the effectiveness of the composition is a constant content of glycated hemoglobin in the blood within 10 days.</description><identifier>ISSN: 1022-9760</identifier><identifier>EISSN: 1572-8935</identifier><identifier>DOI: 10.1007/s10965-022-03225-w</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animal experimentation ; Blood ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Chitosan ; Composition ; Diabetes therapy ; Dosage ; Effectiveness ; Gastrointestinal system ; Glycosylated hemoglobin ; Hemoglobin ; Industrial Chemistry/Chemical Engineering ; Insulin ; Multilayers ; Nanoparticles ; Nanostructure ; Original Paper ; Polymer Sciences ; Proteases ; Type 1 diabetes</subject><ispartof>Journal of polymer research, 2022-09, Vol.29 (9), Article 378</ispartof><rights>The Polymer Society, Taipei 2022. 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The size of the fully formed multicomponent system was 178 nm.The outer layer of chitosan protects insulin from the damaging effects of low pH-medium and proteolytic enzymes of the gastrointestinal tract when the composition is taken orally. Chitosan simultaneously performs a transport function to deliver insulin into the bloodstream. In experiments on experimental animals with artificially induced type 1 diabetes, it was found that the effectiveness and duration of hypoglycemic action of the composition depends on the amount of insulin in the dose. The composition containing 50 IU of insulin per dose provides a rapid decrease glucose level in the blood and maintains it at the level of the intact group for 3 h. After 6 h the efficacy of the composition is comparable to that of insulin injection. A fundamentally important indicator of the effectiveness of the composition is a constant content of glycated hemoglobin in the blood within 10 days.</description><subject>Animal experimentation</subject><subject>Blood</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chitosan</subject><subject>Composition</subject><subject>Diabetes therapy</subject><subject>Dosage</subject><subject>Effectiveness</subject><subject>Gastrointestinal system</subject><subject>Glycosylated hemoglobin</subject><subject>Hemoglobin</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Insulin</subject><subject>Multilayers</subject><subject>Nanoparticles</subject><subject>Nanostructure</subject><subject>Original Paper</subject><subject>Polymer Sciences</subject><subject>Proteases</subject><subject>Type 1 diabetes</subject><issn>1022-9760</issn><issn>1572-8935</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMouK7-AU8Fz12TtEkab8viF6x40XNI08mSpR9r0rr035u1wiKIzGGGmfeZSV6ErgleEIzFbSBYcpZiSlOcUcrS_QmaESZoWsiMncb6MJKC43N0EcIWY8YEL2bo7mWoe1frEXzS6rYLvR9MP3iokjCGHprEdj7pvK4T14ahdm1SQe0-wY-X6MzqOsDVT56j94f7t9VTun59fF4t16nJCO9Tm0uWk4IYUzIrc1GUmrHSlGCIBk4tsBIbyyTLpMhBEGsxLUkpKdMEKltmc3Qz7d357mOA0KttN_g2nlRUxM8zzGV-VG10Dcq1tuu9No0LRi0FyTjBueRRtfhDFaOCxpmuBeti_xdAJ8D4LgQPVu28a7QfFcHqYL2arFfRX_VtvdpHKJugEMXtBvzxxf9QX7uOhrM</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Apryatina, Kristina V.</creator><creator>Glazova, Irina A.</creator><creator>Koryagin, Alexander S.</creator><creator>Zaitsev, Sergey D.</creator><creator>Smirnova, Larisa A.</creator><general>Springer Netherlands</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0001-9207-1524</orcidid><orcidid>https://orcid.org/0000-0002-8629-688X</orcidid><orcidid>https://orcid.org/0000-0002-8897-4437</orcidid></search><sort><creationdate>20220901</creationdate><title>Multilayer nanostructured system for oral insulin delivery</title><author>Apryatina, Kristina V. ; Glazova, Irina A. ; Koryagin, Alexander S. ; Zaitsev, Sergey D. ; Smirnova, Larisa A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-f4954181ccb5f9478ba55bcbec1ae62fe5b0cf5953974e71ff02b1b925a1edfb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animal experimentation</topic><topic>Blood</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chitosan</topic><topic>Composition</topic><topic>Diabetes therapy</topic><topic>Dosage</topic><topic>Effectiveness</topic><topic>Gastrointestinal system</topic><topic>Glycosylated hemoglobin</topic><topic>Hemoglobin</topic><topic>Industrial Chemistry/Chemical Engineering</topic><topic>Insulin</topic><topic>Multilayers</topic><topic>Nanoparticles</topic><topic>Nanostructure</topic><topic>Original Paper</topic><topic>Polymer Sciences</topic><topic>Proteases</topic><topic>Type 1 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Apryatina, Kristina V.</creatorcontrib><creatorcontrib>Glazova, Irina A.</creatorcontrib><creatorcontrib>Koryagin, Alexander S.</creatorcontrib><creatorcontrib>Zaitsev, Sergey D.</creatorcontrib><creatorcontrib>Smirnova, Larisa A.</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of polymer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Apryatina, Kristina V.</au><au>Glazova, Irina A.</au><au>Koryagin, Alexander S.</au><au>Zaitsev, Sergey D.</au><au>Smirnova, Larisa A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multilayer nanostructured system for oral insulin delivery</atitle><jtitle>Journal of polymer research</jtitle><stitle>J Polym Res</stitle><date>2022-09-01</date><risdate>2022</risdate><volume>29</volume><issue>9</issue><artnum>378</artnum><issn>1022-9760</issn><eissn>1572-8935</eissn><abstract>A method to obtain a multilayer insulin-containing composition in a nanostructured form consisting of layers: gold-chitosan-insulin-chitosan nanoparticles was developed. 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| subjects | Animal experimentation Blood Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Chitosan Composition Diabetes therapy Dosage Effectiveness Gastrointestinal system Glycosylated hemoglobin Hemoglobin Industrial Chemistry/Chemical Engineering Insulin Multilayers Nanoparticles Nanostructure Original Paper Polymer Sciences Proteases Type 1 diabetes |
| title | Multilayer nanostructured system for oral insulin delivery |
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