Synthesis of 2-Amino-4H-chromene Derivatives Using InCl3 and Their Antimicrobial Evaluation
A simple, efficient, and green protocol has been developed for the synthesis of 2-amino-4-aryl-4 H -chromene-3-carbonitriles via a one-pot three-component condensation of resorcinol, malononitrile, and substituted aromatic aldehydes in ethanol under reflux using InCl 3 as a catalyst. This methodolo...
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| Veröffentlicht in: | Russian journal of organic chemistry 2022-06, Vol.58 (6), p.913-916 |
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| container_title | Russian journal of organic chemistry |
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| creator | Choudhare, S. S. Bhosale, V. N. Chopade, M. |
| description | A simple, efficient, and green protocol has been developed for the synthesis of 2-amino-4-aryl-4
H
-chromene-3-carbonitriles via a one-pot three-component condensation of resorcinol, malononitrile, and substituted aromatic aldehydes in ethanol under reflux using InCl
3
as a catalyst. This methodology has a number of advantages such as the use of a very small amount of catalyst, easy access, short reaction time, easy workup, high yields, and nontoxicity of the catalyst and solvent. |
| doi_str_mv | 10.1134/S1070428022060227 |
| format | Article |
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H
-chromene-3-carbonitriles via a one-pot three-component condensation of resorcinol, malononitrile, and substituted aromatic aldehydes in ethanol under reflux using InCl
3
as a catalyst. This methodology has a number of advantages such as the use of a very small amount of catalyst, easy access, short reaction time, easy workup, high yields, and nontoxicity of the catalyst and solvent.</description><identifier>ISSN: 1070-4280</identifier><identifier>EISSN: 1608-3393</identifier><identifier>DOI: 10.1134/S1070428022060227</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Aldehydes ; Antiinfectives and antibacterials ; Catalysts ; Chemistry ; Chemistry and Materials Science ; Ethanol ; Malononitrile ; Organic Chemistry ; Reaction time ; Synthesis</subject><ispartof>Russian journal of organic chemistry, 2022-06, Vol.58 (6), p.913-916</ispartof><rights>Pleiades Publishing, Ltd. 2022</rights><rights>Pleiades Publishing, Ltd. 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c246t-ed30de7b3f525e943c61872104c1c4b42d46b567b139fc95a645cb969e350e763</citedby><cites>FETCH-LOGICAL-c246t-ed30de7b3f525e943c61872104c1c4b42d46b567b139fc95a645cb969e350e763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1070428022060227$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1070428022060227$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,41479,42548,51310</link.rule.ids></links><search><creatorcontrib>Choudhare, S. S.</creatorcontrib><creatorcontrib>Bhosale, V. N.</creatorcontrib><creatorcontrib>Chopade, M.</creatorcontrib><title>Synthesis of 2-Amino-4H-chromene Derivatives Using InCl3 and Their Antimicrobial Evaluation</title><title>Russian journal of organic chemistry</title><addtitle>Russ J Org Chem</addtitle><description>A simple, efficient, and green protocol has been developed for the synthesis of 2-amino-4-aryl-4
H
-chromene-3-carbonitriles via a one-pot three-component condensation of resorcinol, malononitrile, and substituted aromatic aldehydes in ethanol under reflux using InCl
3
as a catalyst. This methodology has a number of advantages such as the use of a very small amount of catalyst, easy access, short reaction time, easy workup, high yields, and nontoxicity of the catalyst and solvent.</description><subject>Aldehydes</subject><subject>Antiinfectives and antibacterials</subject><subject>Catalysts</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Ethanol</subject><subject>Malononitrile</subject><subject>Organic Chemistry</subject><subject>Reaction time</subject><subject>Synthesis</subject><issn>1070-4280</issn><issn>1608-3393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1UM1LwzAUD6LgnP4B3gKeo_lq2hzHnG4w8LDt5KG06euW0aYz6Qr7782Y4EG8vPfg9_X4IfTI6DNjQr6sGE2p5BnlnKo40is0YopmRAgtruMdYXLGb9FdCHtKqWRSjNDn6uT6HQQbcFdjTiatdR2Rc2J2vmvBAX4Fb4eitwMEvAnWbfHCTRuBC1fh9Q6sxxPX29Ya35W2aPBsKJpj5HfuHt3URRPg4WeP0eZttp7OyfLjfTGdLInhUvUEKkErSEtRJzwBLYVRLEs5o9IwI0vJK6nKRKUlE7o2OimUTEyplQaRUEiVGKOni-_Bd19HCH2-747excicK611xtPoOkbswoqPhuChzg_etoU_5Yzm5w7zPx1GDb9oQuS6Lfhf5_9F36T2cVc</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Choudhare, S. S.</creator><creator>Bhosale, V. N.</creator><creator>Chopade, M.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20220601</creationdate><title>Synthesis of 2-Amino-4H-chromene Derivatives Using InCl3 and Their Antimicrobial Evaluation</title><author>Choudhare, S. S. ; Bhosale, V. N. ; Chopade, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c246t-ed30de7b3f525e943c61872104c1c4b42d46b567b139fc95a645cb969e350e763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aldehydes</topic><topic>Antiinfectives and antibacterials</topic><topic>Catalysts</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Ethanol</topic><topic>Malononitrile</topic><topic>Organic Chemistry</topic><topic>Reaction time</topic><topic>Synthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choudhare, S. S.</creatorcontrib><creatorcontrib>Bhosale, V. N.</creatorcontrib><creatorcontrib>Chopade, M.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian journal of organic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choudhare, S. S.</au><au>Bhosale, V. N.</au><au>Chopade, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of 2-Amino-4H-chromene Derivatives Using InCl3 and Their Antimicrobial Evaluation</atitle><jtitle>Russian journal of organic chemistry</jtitle><stitle>Russ J Org Chem</stitle><date>2022-06-01</date><risdate>2022</risdate><volume>58</volume><issue>6</issue><spage>913</spage><epage>916</epage><pages>913-916</pages><issn>1070-4280</issn><eissn>1608-3393</eissn><abstract>A simple, efficient, and green protocol has been developed for the synthesis of 2-amino-4-aryl-4
H
-chromene-3-carbonitriles via a one-pot three-component condensation of resorcinol, malononitrile, and substituted aromatic aldehydes in ethanol under reflux using InCl
3
as a catalyst. This methodology has a number of advantages such as the use of a very small amount of catalyst, easy access, short reaction time, easy workup, high yields, and nontoxicity of the catalyst and solvent.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1070428022060227</doi><tpages>4</tpages></addata></record> |
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| subjects | Aldehydes Antiinfectives and antibacterials Catalysts Chemistry Chemistry and Materials Science Ethanol Malononitrile Organic Chemistry Reaction time Synthesis |
| title | Synthesis of 2-Amino-4H-chromene Derivatives Using InCl3 and Their Antimicrobial Evaluation |
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