Synthesis of 2-Amino-4H-chromene Derivatives Using InCl3 and Their Antimicrobial Evaluation

A simple, efficient, and green protocol has been developed for the synthesis of 2-amino-4-aryl-4 H -chromene-3-carbonitriles via a one-pot three-component condensation of resorcinol, malononitrile, and substi­tuted aromatic aldehydes in ethanol under reflux using InCl 3 as a catalyst. This methodology has a number of advantages such as the use of a very small amount of catalyst, easy access, short reaction time, easy workup, high yields, and nontoxicity of the catalyst and solvent.