Atrial Natriuretic Peptide (ANP) Suppress λ-Carrageenan-Induced Acute Paw Edema by Modulating Pro-inflammatory Genes in Swiss Albino Mice

The present study was designed to investigate the anti-inflammatory activity of atrial natriuretic peptide (ANP) using λ-Carrageenan (λ-CAN)—induced acute inflammation in the mice model. A single subplantar injection of λ-CAN (1% in 0.9% saline) triggers acute paw edema. ANP (2 μg/kg body weight/day...

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Veröffentlicht in:	International journal of peptide research and therapeutics 2022-08, Vol.28 (5), Article 138
Hauptverfasser:	Kalaiarasu, Lakshmi Priya, Babu, Aadhil Ashwaq, Krishnan, Kalaiselvi, Dhanusu, Suresh, Vellaichamy, Elangovan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Anatomy Anti-inflammatory agents Aspirin Atrial natriuretic peptide Biochemistry Biomedical and Life Sciences Body weight Carrageenans Cyclooxygenase-2 Cytokines Edema Histology Inflammation Interleukin 1 Interleukin 6 Latency Life Sciences Molecular Medicine Morphology Pain Peptides Peroxidase Pharmaceutical Sciences/Technology Pharmacology/Toxicology Polymer Sciences Prostaglandin E2 Tumor necrosis factor Tumors
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Zusammenfassung:	The present study was designed to investigate the anti-inflammatory activity of atrial natriuretic peptide (ANP) using λ-Carrageenan (λ-CAN)—induced acute inflammation in the mice model. A single subplantar injection of λ-CAN (1% in 0.9% saline) triggers acute paw edema. ANP (2 μg/kg body weight/day/i.p) was given 30 min prior or after administration of λ-CAN. The standard drug Aspirin (ASP) treated group was used as a positive control. A marked increase in paw thickness (32.56% p
ISSN:	1573-3904 1573-3149 1573-3904
DOI:	10.1007/s10989-022-10444-8