Aggregation‐Induced Emission (AIE) Photosensitizer Combined Polydopamine Nanomaterials for Organelle‐Targeting Photodynamic and Photothermal Therapy by the Recognition of Sialic Acid
The construction of organelle‐targeting nanomaterials is an effective way to improve tumor imaging and treatment. Here, a new type of composite nanomaterial named as PTTPB is developed. PTTPB is composed of organelle‐targeting aggregation‐induced emission photosensitizer TTPB and polydopamine nanoma...
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| Veröffentlicht in: | Advanced healthcare materials 2022-08, Vol.11 (15), p.e2200242-n/a |
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| creator | Li, Shuo Chen, Yuzhi He, Peinan Ma, Yufan Cai, Yajie Hou, Xinhui Zhang, Guoyang Zhang, Xin Wang, Zhuo |
| description | The construction of organelle‐targeting nanomaterials is an effective way to improve tumor imaging and treatment. Here, a new type of composite nanomaterial named as PTTPB is developed. PTTPB is composed of organelle‐targeting aggregation‐induced emission photosensitizer TTPB and polydopamine nanomaterials. With the functional modification of TTPB, PTTPB can recognize sialic acid on the cell membrane and present mitochondrial targeted capabilities. The intake of PTTPB in cancerous cells can be increased by the recognition process of cell membrane. PTTPB can generate singlet oxygen for photodynamic therapy (PDT), and present good photothermal conversion ability with irradiation. The PTTPB with organelle‐targeting imaging‐guided can realize the tumor ablation with the synergistic effect of PDT and photothermal therapy.
A new kind of nanocomposite (PTTPB) is explored for tumor imaging and ablation. PTTPB is constructed with aggregation‐induced emission photosensitizer TTPB and polydopamine nanomaterials. With the aid of positive charge and phenylboronic acid of TTPB, PTTPB can recognize sialic acid and target mitochondria. PTTPB could realize the tumor ablation by the synergetic effect of photodynamic therapy and photothermal therapy. |
| doi_str_mv | 10.1002/adhm.202200242 |
| format | Article |
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A new kind of nanocomposite (PTTPB) is explored for tumor imaging and ablation. PTTPB is constructed with aggregation‐induced emission photosensitizer TTPB and polydopamine nanomaterials. With the aid of positive charge and phenylboronic acid of TTPB, PTTPB can recognize sialic acid and target mitochondria. PTTPB could realize the tumor ablation by the synergetic effect of photodynamic therapy and photothermal therapy.</description><identifier>ISSN: 2192-2640</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.202200242</identifier><identifier>PMID: 35613621</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Ablation ; Agglomeration ; Animals ; Cell membranes ; Emission ; Humans ; Indoles ; Mice ; Mice, Inbred BALB C ; Mitochondria ; N-Acetylneuraminic Acid - therapeutic use ; Nanomaterials ; Nanostructures ; Nanotechnology ; Neoplasms - drug therapy ; organelle targeting ; Photochemotherapy - methods ; Photodynamic therapy ; Photosensitizing Agents - pharmacology ; Photosensitizing Agents - therapeutic use ; Photothermal conversion ; Photothermal Therapy ; Polymers ; Radiation ; Recognition ; sialic acid ; Singlet oxygen ; Synergistic effect ; Tumors</subject><ispartof>Advanced healthcare materials, 2022-08, Vol.11 (15), p.e2200242-n/a</ispartof><rights>2022 Wiley‐VCH GmbH</rights><rights>2022 Wiley-VCH GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3732-ba60d64375b56b4a9b29ce38af1fc339706e4c0771ab8cb4a5f65c5456a782e83</citedby><cites>FETCH-LOGICAL-c3732-ba60d64375b56b4a9b29ce38af1fc339706e4c0771ab8cb4a5f65c5456a782e83</cites><orcidid>0000-0002-2858-7646</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadhm.202200242$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadhm.202200242$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35613621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Shuo</creatorcontrib><creatorcontrib>Chen, Yuzhi</creatorcontrib><creatorcontrib>He, Peinan</creatorcontrib><creatorcontrib>Ma, Yufan</creatorcontrib><creatorcontrib>Cai, Yajie</creatorcontrib><creatorcontrib>Hou, Xinhui</creatorcontrib><creatorcontrib>Zhang, Guoyang</creatorcontrib><creatorcontrib>Zhang, Xin</creatorcontrib><creatorcontrib>Wang, Zhuo</creatorcontrib><title>Aggregation‐Induced Emission (AIE) Photosensitizer Combined Polydopamine Nanomaterials for Organelle‐Targeting Photodynamic and Photothermal Therapy by the Recognition of Sialic Acid</title><title>Advanced healthcare materials</title><addtitle>Adv Healthc Mater</addtitle><description>The construction of organelle‐targeting nanomaterials is an effective way to improve tumor imaging and treatment. Here, a new type of composite nanomaterial named as PTTPB is developed. PTTPB is composed of organelle‐targeting aggregation‐induced emission photosensitizer TTPB and polydopamine nanomaterials. With the functional modification of TTPB, PTTPB can recognize sialic acid on the cell membrane and present mitochondrial targeted capabilities. The intake of PTTPB in cancerous cells can be increased by the recognition process of cell membrane. PTTPB can generate singlet oxygen for photodynamic therapy (PDT), and present good photothermal conversion ability with irradiation. The PTTPB with organelle‐targeting imaging‐guided can realize the tumor ablation with the synergistic effect of PDT and photothermal therapy.
A new kind of nanocomposite (PTTPB) is explored for tumor imaging and ablation. PTTPB is constructed with aggregation‐induced emission photosensitizer TTPB and polydopamine nanomaterials. With the aid of positive charge and phenylboronic acid of TTPB, PTTPB can recognize sialic acid and target mitochondria. PTTPB could realize the tumor ablation by the synergetic effect of photodynamic therapy and photothermal therapy.</description><subject>Ablation</subject><subject>Agglomeration</subject><subject>Animals</subject><subject>Cell membranes</subject><subject>Emission</subject><subject>Humans</subject><subject>Indoles</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mitochondria</subject><subject>N-Acetylneuraminic Acid - therapeutic use</subject><subject>Nanomaterials</subject><subject>Nanostructures</subject><subject>Nanotechnology</subject><subject>Neoplasms - drug therapy</subject><subject>organelle targeting</subject><subject>Photochemotherapy - methods</subject><subject>Photodynamic therapy</subject><subject>Photosensitizing Agents - pharmacology</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>Photothermal conversion</subject><subject>Photothermal Therapy</subject><subject>Polymers</subject><subject>Radiation</subject><subject>Recognition</subject><subject>sialic acid</subject><subject>Singlet oxygen</subject><subject>Synergistic effect</subject><subject>Tumors</subject><issn>2192-2640</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQhy0EolXplSOyxAUOu_hP7CTHaFnoSoVWsJwjx55kXSX2YmeF0lMfgefhcXgSvEpZjvhiz-ibbyz9EHpJyZISwt4psxuWjDCWiow9QeeMlmzBpCifnt4ZOUOXMd6RdKSgsqDP0RkXknLJ6Dn6VXVdgE6N1rvfDz83zhw0GLwebIyphd9Um_VbfLvzo4_goh3tPQS88kNjXeJufT8Zv1dDqvBn5fygRghW9RG3PuCb0CkHfQ9JvVWhg9G6braZyaUpjZUzc2PcQRhUj7fpVvsJNxNOLfwFtO-cPf4P-xZ_Te40VWlrXqBnbVoEl4_3Bfr2Yb1dXS2ubz5uVtX1QvOcs0WjJDEy47lohGwyVTas1MAL1dJWc17mREKmSZ5T1RQ6AaKVQotMSJUXDAp-gV7P3n3w3w8Qx_rOH4JLK2smy1wwkguSqOVM6eBjDNDW-2AHFaaakvqYVn1Mqz6llQZePWoPzQDmhP_NJgHlDPywPUz_0dXV-6tP_-R_AHOMpjs</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Li, Shuo</creator><creator>Chen, Yuzhi</creator><creator>He, Peinan</creator><creator>Ma, Yufan</creator><creator>Cai, Yajie</creator><creator>Hou, Xinhui</creator><creator>Zhang, Guoyang</creator><creator>Zhang, Xin</creator><creator>Wang, Zhuo</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T5</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7TO</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><orcidid>https://orcid.org/0000-0002-2858-7646</orcidid></search><sort><creationdate>20220801</creationdate><title>Aggregation‐Induced Emission (AIE) Photosensitizer Combined Polydopamine Nanomaterials for Organelle‐Targeting Photodynamic and Photothermal Therapy by the Recognition of Sialic Acid</title><author>Li, Shuo ; Chen, Yuzhi ; He, Peinan ; Ma, Yufan ; Cai, Yajie ; Hou, Xinhui ; Zhang, Guoyang ; Zhang, Xin ; Wang, Zhuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3732-ba60d64375b56b4a9b29ce38af1fc339706e4c0771ab8cb4a5f65c5456a782e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Ablation</topic><topic>Agglomeration</topic><topic>Animals</topic><topic>Cell membranes</topic><topic>Emission</topic><topic>Humans</topic><topic>Indoles</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mitochondria</topic><topic>N-Acetylneuraminic Acid - therapeutic use</topic><topic>Nanomaterials</topic><topic>Nanostructures</topic><topic>Nanotechnology</topic><topic>Neoplasms - drug therapy</topic><topic>organelle targeting</topic><topic>Photochemotherapy - methods</topic><topic>Photodynamic therapy</topic><topic>Photosensitizing Agents - pharmacology</topic><topic>Photosensitizing Agents - therapeutic use</topic><topic>Photothermal conversion</topic><topic>Photothermal Therapy</topic><topic>Polymers</topic><topic>Radiation</topic><topic>Recognition</topic><topic>sialic acid</topic><topic>Singlet oxygen</topic><topic>Synergistic effect</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Shuo</creatorcontrib><creatorcontrib>Chen, Yuzhi</creatorcontrib><creatorcontrib>He, Peinan</creatorcontrib><creatorcontrib>Ma, Yufan</creatorcontrib><creatorcontrib>Cai, Yajie</creatorcontrib><creatorcontrib>Hou, Xinhui</creatorcontrib><creatorcontrib>Zhang, Guoyang</creatorcontrib><creatorcontrib>Zhang, Xin</creatorcontrib><creatorcontrib>Wang, Zhuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Immunology Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><jtitle>Advanced healthcare materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Shuo</au><au>Chen, Yuzhi</au><au>He, Peinan</au><au>Ma, Yufan</au><au>Cai, Yajie</au><au>Hou, Xinhui</au><au>Zhang, Guoyang</au><au>Zhang, Xin</au><au>Wang, Zhuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aggregation‐Induced Emission (AIE) Photosensitizer Combined Polydopamine Nanomaterials for Organelle‐Targeting Photodynamic and Photothermal Therapy by the Recognition of Sialic Acid</atitle><jtitle>Advanced healthcare materials</jtitle><addtitle>Adv Healthc Mater</addtitle><date>2022-08-01</date><risdate>2022</risdate><volume>11</volume><issue>15</issue><spage>e2200242</spage><epage>n/a</epage><pages>e2200242-n/a</pages><issn>2192-2640</issn><eissn>2192-2659</eissn><abstract>The construction of organelle‐targeting nanomaterials is an effective way to improve tumor imaging and treatment. Here, a new type of composite nanomaterial named as PTTPB is developed. PTTPB is composed of organelle‐targeting aggregation‐induced emission photosensitizer TTPB and polydopamine nanomaterials. With the functional modification of TTPB, PTTPB can recognize sialic acid on the cell membrane and present mitochondrial targeted capabilities. The intake of PTTPB in cancerous cells can be increased by the recognition process of cell membrane. PTTPB can generate singlet oxygen for photodynamic therapy (PDT), and present good photothermal conversion ability with irradiation. The PTTPB with organelle‐targeting imaging‐guided can realize the tumor ablation with the synergistic effect of PDT and photothermal therapy.
A new kind of nanocomposite (PTTPB) is explored for tumor imaging and ablation. PTTPB is constructed with aggregation‐induced emission photosensitizer TTPB and polydopamine nanomaterials. With the aid of positive charge and phenylboronic acid of TTPB, PTTPB can recognize sialic acid and target mitochondria. PTTPB could realize the tumor ablation by the synergetic effect of photodynamic therapy and photothermal therapy.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35613621</pmid><doi>10.1002/adhm.202200242</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-2858-7646</orcidid></addata></record> |
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| subjects | Ablation Agglomeration Animals Cell membranes Emission Humans Indoles Mice Mice, Inbred BALB C Mitochondria N-Acetylneuraminic Acid - therapeutic use Nanomaterials Nanostructures Nanotechnology Neoplasms - drug therapy organelle targeting Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - pharmacology Photosensitizing Agents - therapeutic use Photothermal conversion Photothermal Therapy Polymers Radiation Recognition sialic acid Singlet oxygen Synergistic effect Tumors |
| title | Aggregation‐Induced Emission (AIE) Photosensitizer Combined Polydopamine Nanomaterials for Organelle‐Targeting Photodynamic and Photothermal Therapy by the Recognition of Sialic Acid |
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