Aggregation‐Induced Emission (AIE) Photosensitizer Combined Polydopamine Nanomaterials for Organelle‐Targeting Photodynamic and Photothermal Therapy by the Recognition of Sialic Acid

The construction of organelle‐targeting nanomaterials is an effective way to improve tumor imaging and treatment. Here, a new type of composite nanomaterial named as PTTPB is developed. PTTPB is composed of organelle‐targeting aggregation‐induced emission photosensitizer TTPB and polydopamine nanomaterials. With the functional modification of TTPB, PTTPB can recognize sialic acid on the cell membrane and present mitochondrial targeted capabilities. The intake of PTTPB in cancerous cells can be increased by the recognition process of cell membrane. PTTPB can generate singlet oxygen for photodynamic therapy (PDT), and present good photothermal conversion ability with irradiation. The PTTPB with organelle‐targeting imaging‐guided can realize the tumor ablation with the synergistic effect of PDT and photothermal therapy. A new kind of nanocomposite (PTTPB) is explored for tumor imaging and ablation. PTTPB is constructed with aggregation‐induced emission photosensitizer TTPB and polydopamine nanomaterials. With the aid of positive charge and phenylboronic acid of TTPB, PTTPB can recognize sialic acid and target mitochondria. PTTPB could realize the tumor ablation by the synergetic effect of photodynamic therapy and photothermal therapy.