Palladium‐Catalyzed Selective C‐F Bond Cleavage of Trifluoropropanamides Leading to (Z)‐N‐α‐Fluorovinylindoles

Palladium‐Catalyzed Selective C‐F Bond Cleavage of Trifluoropropanamides Leading to (Z)‐N‐α‐Fluorovinylindoles

A defluorinative heteroarylation of trifluoropropanamides through N‐chelation‐assisted palladium‐catalyzed selective C−F activation has been developed. This reaction is compatible with a variety of trifluoropropanamides and indoles under mild reaction conditions to provide the stereospecific (Z)‐N‐α...

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Veröffentlicht in:Advanced synthesis & catalysis 2022-08, Vol.364 (15), p.2546-2550
Hauptverfasser: Du, Xin, Zhang, Wei‐Ming, Zhang, Xing‐Guo, Tu, Hai‐Yong
Format: Artikel
Sprache:eng
Schlagworte:
Chelation
Defluorination
heteroarylation
Indoles
N-chelation
α-fluorovinylindoles
Palladium
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Zusammenfassung:A defluorinative heteroarylation of trifluoropropanamides through N‐chelation‐assisted palladium‐catalyzed selective C−F activation has been developed. This reaction is compatible with a variety of trifluoropropanamides and indoles under mild reaction conditions to provide the stereospecific (Z)‐N‐α‐fluorovinylindoles in moderate to good yields.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202200352