RESEARCH FOR DEVELOPMENT OF NUMERICAL MODEL FOR EVALUATING ODORANT IN INDOOR ENVIRONMENT: NUMERICAL IDENTIFICATION OF DIFFERENCES BETWEEN ORTHONASAL AND RETRONASAL PATHWAYS OF INHALED GAS-PHASE ACETONE IN A HUMAN RESPIRATORY TRACT

In this study, following the procedure of the perceptive air quality test described in ISO 16000-28 and ISO 16000-30, we numerically analyzed the odorant transportation from the odorant generator to human breathing zone using acetone which is considered as a standard substance for pi-scale evaluation. For the evaluation of access to olfactory receptors under a transient breathing cycle, the acetone adsorption flux to the olfactory epithelial cells was calculated by using computer simulated person (CSP) with numerical respiratory tract model and physiologically based pharmacokinetic (PBPK) model.