Collagen – Zinc Oxide Nanoparticles (ZnO NPs) Composites for Wound Healing – A Review

Fish Collagen which is also called as Marine collagen has gained immense attention in the recent years as an appropriate alternative to mammalian collagen. Fish collagen is essentially the superhero of collagen sourced from animals. Fish collagen is made up of mostly Type 1 collagen, which makes up to 70 percent of total skin. Collagen is found to heal wounds by attracting new skin cells to the wound site. It promotes healing and provide platform for new tissue growth. Zinc Oxide Nanoparticles are nanoparticles of ZnO that have diameter less than 100 nanometres. Recently, ZnO Nanoparticles have shown to disrupt bacterial cell membrane integrity, reduce cell surface hydrophobicity and enhancement of intracellular bacterial killing. The ZnO nanoparticles were synthesized from the plant. The paper will describe the potency of fish skin waste, problems in healing burn injuries, collagen extraction, green synthesis of ZnO NPs, collagen and ZnO NPs applications in wound dressing. Since ZnO nanoparticles have much anti-bacterial activity it can be combined with collagen and characterized for the application in wound healing management.