Facile synthesis, antimicrobial, and anti‐inflammatory activities of novel isoxazolyl imidazoisoxazoles

A copper iodide promoted cyclization for the synthesis of isoxazolyl imidazo[1,2‐b]isoxazoles 3 in a one‐pot procedure has been investigated by interaction of 3‐aminoisoxazole 1 with nitrostyrylisoxazoles 2 under aerial oxidation condition. The newly synthesized compounds 3a–l were screened for thei...

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Veröffentlicht in:	Journal of heterocyclic chemistry 2022-08, Vol.59 (8), p.1341-1349
Hauptverfasser:	Saini, Rama Krishna, Nagaraju, Dharavath, Malladi, Srinivas Reddy, Rajanarendar, Eligeti
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiinfectives and antibacterials Oxidation Synthesis
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Beschreibung
Zusammenfassung:	A copper iodide promoted cyclization for the synthesis of isoxazolyl imidazo[1,2‐b]isoxazoles 3 in a one‐pot procedure has been investigated by interaction of 3‐aminoisoxazole 1 with nitrostyrylisoxazoles 2 under aerial oxidation condition. The newly synthesized compounds 3a–l were screened for their in vitro antimicrobial and anti‐inflammatory activities.
ISSN:	0022-152X 1943-5193
DOI:	10.1002/jhet.4473