Effects of nanoaggregation on isoindigo-based fluorophores for near-infrared bioimaging applications

Effects of nanoaggregation on isoindigo-based fluorophores for near-infrared bioimaging applications

In this work, we have taken a donor-acceptor-donor (D-A-D) fluorophore ( II-EDOT-TPA ) and encapsulated it using a linear dendritic block copolymer (LDBC). In parallel, a polyethylene glycol derivative ( PEG-II-EDOT-TPA ) was synthesized. The self-assembly and colloidal properties of both nanoaggreg...

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Veröffentlicht in:Molecular systems design & engineering 2022-08, Vol.7 (8), p.96-914
Hauptverfasser: Sparks, Nicholas E, Dorris, Austin, Vijayan, Sajith M, Chandrasiri, Indika, Zia, Mohammad Farid, Flynt, Alex, Hammer, Nathan I, Watkins, Davita L
Format: Artikel
Sprache:eng
Schlagworte:
Block copolymers
Chemical compounds
Encapsulation
Lysosomes
Medical imaging
Polyethylene glycol
Self-assembly
Toxicity
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Zusammenfassung:In this work, we have taken a donor-acceptor-donor (D-A-D) fluorophore ( II-EDOT-TPA ) and encapsulated it using a linear dendritic block copolymer (LDBC). In parallel, a polyethylene glycol derivative ( PEG-II-EDOT-TPA ) was synthesized. The self-assembly and colloidal properties of both nanoaggregates were comparatively assessed. Photophysical and morphological characterization of the LDBC encapsulated II-EDOT-TPA and PEG-II-EDOT-TPA nanoaggregates was performed, which showed the photophysical and morphological properties differed greatly when comparing the two. Both nanoaggregate types were incubated with HEK-293 cells in order to measure cell viability and perform confocal fluorescence microscopy. Minimal cytotoxicity values (
ISSN:2058-9689
2058-9689
DOI:10.1039/d2me00014h