Navigating double negatives: new pathways for regulating TFH differentiation

Navigating double negatives: new pathways for regulating TFH differentiation

The transcription factors Foxp1 and Foxo1 inhibit the differentiation of follicular helper T cells. On the other hand, the E3 ligase Itch targets Foxo1 for degradation to promote such differentiation.

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Bibliographische Detailangaben
Veröffentlicht in:Nature immunology 2014-07, Vol.15 (7), p.597-599
Hauptverfasser: Yu, Di, Chen, Yaping, Leong, Yew Ann
Format: Artikel
Sprache:eng
Schlagworte:
631/250/1619/554/1898/1270
631/250/2502
Biomedicine
Cell differentiation
FOXO1 protein
Foxp1 protein
Immunology
Infectious Diseases
Lymphocytes T
news-and-views
Transcription factors
Ubiquitin-protein ligase
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Beschreibung
Zusammenfassung:The transcription factors Foxp1 and Foxo1 inhibit the differentiation of follicular helper T cells. On the other hand, the E3 ligase Itch targets Foxo1 for degradation to promote such differentiation.
ISSN:1529-2908
1529-2916
DOI:10.1038/ni.2922