classical live attenuated vaccine for sheep pox
A classical live attenuated sheep pox vaccine was prepared using the Ranipet strain of sheep pox virus (SPV) at the 50th passage in a secondary lamb testicular cell system. The TCID50 and RD50 were 10(9.63)/ml and 10(9.51)/ml. respectively. The SID50 of SPV challenge virus was 10(5)/ml. The vaccine...
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| Veröffentlicht in: | Tropical animal health and production 2004-05, Vol.36 (4), p.307-320 |
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| creator | Bhanuprakash, V Indrani, B.K Hedge, R Kumar, M.M Moorthy, A.R.S |
| description | A classical live attenuated sheep pox vaccine was prepared using the Ranipet strain of sheep pox virus (SPV) at the 50th passage in a secondary lamb testicular cell system. The TCID50 and RD50 were 10(9.63)/ml and 10(9.51)/ml. respectively. The SID50 of SPV challenge virus was 10(5)/ml. The vaccine was found to have no adverse effects in laboratory animals, and was safe and effective in SPV seronegative lambs. In the field, 660 sheep were vaccinated with an immunizing dose containing 1 x 10(2) TCID50. Randomly selected vaccinated sheep mounted good cell-mediated immunity and humoral responses as measured by glucose utilization test and serum neutralization test, respectively, for the study period of 6 months. |
| doi_str_mv | 10.1023/B:TROP.0000026661.88631.50 |
| format | Article |
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The TCID50 and RD50 were 10(9.63)/ml and 10(9.51)/ml. respectively. The SID50 of SPV challenge virus was 10(5)/ml. The vaccine was found to have no adverse effects in laboratory animals, and was safe and effective in SPV seronegative lambs. In the field, 660 sheep were vaccinated with an immunizing dose containing 1 x 10(2) TCID50. Randomly selected vaccinated sheep mounted good cell-mediated immunity and humoral responses as measured by glucose utilization test and serum neutralization test, respectively, for the study period of 6 months.</description><identifier>ISSN: 0049-4747</identifier><identifier>EISSN: 1573-7438</identifier><identifier>DOI: 10.1023/B:TROP.0000026661.88631.50</identifier><identifier>PMID: 15241965</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; antibody formation ; Body Temperature ; Capripoxvirus - immunology ; cell lines ; Cell-mediated immunity ; dosage ; Female ; fever ; Glucose - metabolism ; Guinea Pigs ; Humoral immunity ; Immunization ; Immunization - methods ; Immunization - veterinary ; Laboratory animals ; Laboratory tests ; Lamb ; lambs ; live vaccines ; Male ; Mice ; Neutralization ; neutralization tests ; Neutralization Tests - veterinary ; Poxviridae Infections - immunology ; Poxviridae Infections - prevention & control ; Poxviridae Infections - veterinary ; Poxviridae Infections - virology ; Sheep ; Sheep Diseases - immunology ; Sheep Diseases - prevention & control ; Sheep Diseases - virology ; Sheeppox virus ; Side effects ; vaccination ; vaccine development ; Vaccines ; Vaccines, Attenuated - adverse effects ; Vaccines, Attenuated - immunology ; Vaccines, Attenuated - therapeutic use ; Viral Vaccines - adverse effects ; Viral Vaccines - immunology ; Viral Vaccines - therapeutic use ; Viruses</subject><ispartof>Tropical animal health and production, 2004-05, Vol.36 (4), p.307-320</ispartof><rights>Copyright (c) 2004 Kluwer Academic Publishers</rights><rights>Kluwer Academic Publishers 2004.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-aeb626bf9ccd2a0fe6c46c51b4e61cb94c044a616d6ed3702aa993a9067f9b473</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15241965$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bhanuprakash, V</creatorcontrib><creatorcontrib>Indrani, B.K</creatorcontrib><creatorcontrib>Hedge, R</creatorcontrib><creatorcontrib>Kumar, M.M</creatorcontrib><creatorcontrib>Moorthy, A.R.S</creatorcontrib><title>classical live attenuated vaccine for sheep pox</title><title>Tropical animal health and production</title><addtitle>Trop Anim Health Prod</addtitle><description>A classical live attenuated sheep pox vaccine was prepared using the Ranipet strain of sheep pox virus (SPV) at the 50th passage in a secondary lamb testicular cell system. 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Randomly selected vaccinated sheep mounted good cell-mediated immunity and humoral responses as measured by glucose utilization test and serum neutralization test, respectively, for the study period of 6 months.</description><subject>Animals</subject><subject>antibody formation</subject><subject>Body Temperature</subject><subject>Capripoxvirus - immunology</subject><subject>cell lines</subject><subject>Cell-mediated immunity</subject><subject>dosage</subject><subject>Female</subject><subject>fever</subject><subject>Glucose - metabolism</subject><subject>Guinea Pigs</subject><subject>Humoral immunity</subject><subject>Immunization</subject><subject>Immunization - methods</subject><subject>Immunization - veterinary</subject><subject>Laboratory animals</subject><subject>Laboratory tests</subject><subject>Lamb</subject><subject>lambs</subject><subject>live vaccines</subject><subject>Male</subject><subject>Mice</subject><subject>Neutralization</subject><subject>neutralization tests</subject><subject>Neutralization Tests - veterinary</subject><subject>Poxviridae Infections - immunology</subject><subject>Poxviridae Infections - prevention & control</subject><subject>Poxviridae Infections - veterinary</subject><subject>Poxviridae Infections - virology</subject><subject>Sheep</subject><subject>Sheep Diseases - immunology</subject><subject>Sheep Diseases - prevention & control</subject><subject>Sheep Diseases - virology</subject><subject>Sheeppox virus</subject><subject>Side effects</subject><subject>vaccination</subject><subject>vaccine development</subject><subject>Vaccines</subject><subject>Vaccines, Attenuated - adverse effects</subject><subject>Vaccines, Attenuated - immunology</subject><subject>Vaccines, Attenuated - therapeutic use</subject><subject>Viral Vaccines - adverse effects</subject><subject>Viral Vaccines - immunology</subject><subject>Viral Vaccines - therapeutic use</subject><subject>Viruses</subject><issn>0049-4747</issn><issn>1573-7438</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kEtPwkAUhSdGI4j-BW1wXbzzuu2wE-IrIcEorCfT6VRLCsVOS_Tf2woJK-_mbr5zTvIRMqQwosD43WS8eJu_jqA7hoh0FMfI6UjCCelTGfEwEjw-JX0AoUIRiahHLrxfAVCAGM9Jj0omqELZJ3e2MN7n1hRBke9cYOrabRpTuzTYGWvzjQuysgr8p3PbYFt-X5KzzBTeXR3-gCwfHxbT53A2f3qZ3s9CKyStQ-MSZJhkytqUGcgcWoFW0kQ4pDZRwoIQBimm6FIeATNGKW4UYJSpRER8QG73vduq_Gqcr_WqbKpNO6kZKkljxRRvqeG_lGSM8tZAC433kK1K7yuX6W2Vr031oynoTqie6E6oPgrVf0K1hDZ8fVhokrVLj9GDwRa42QOZKbX5qHKvl-8MumnFkULEfwE8nXlR</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Bhanuprakash, V</creator><creator>Indrani, B.K</creator><creator>Hedge, R</creator><creator>Kumar, M.M</creator><creator>Moorthy, A.R.S</creator><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20040501</creationdate><title>classical live attenuated vaccine for sheep pox</title><author>Bhanuprakash, V ; Indrani, B.K ; Hedge, R ; Kumar, M.M ; Moorthy, A.R.S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-aeb626bf9ccd2a0fe6c46c51b4e61cb94c044a616d6ed3702aa993a9067f9b473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>antibody formation</topic><topic>Body Temperature</topic><topic>Capripoxvirus - 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The TCID50 and RD50 were 10(9.63)/ml and 10(9.51)/ml. respectively. The SID50 of SPV challenge virus was 10(5)/ml. The vaccine was found to have no adverse effects in laboratory animals, and was safe and effective in SPV seronegative lambs. In the field, 660 sheep were vaccinated with an immunizing dose containing 1 x 10(2) TCID50. Randomly selected vaccinated sheep mounted good cell-mediated immunity and humoral responses as measured by glucose utilization test and serum neutralization test, respectively, for the study period of 6 months.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>15241965</pmid><doi>10.1023/B:TROP.0000026661.88631.50</doi><tpages>14</tpages></addata></record> |
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| subjects | Animals antibody formation Body Temperature Capripoxvirus - immunology cell lines Cell-mediated immunity dosage Female fever Glucose - metabolism Guinea Pigs Humoral immunity Immunization Immunization - methods Immunization - veterinary Laboratory animals Laboratory tests Lamb lambs live vaccines Male Mice Neutralization neutralization tests Neutralization Tests - veterinary Poxviridae Infections - immunology Poxviridae Infections - prevention & control Poxviridae Infections - veterinary Poxviridae Infections - virology Sheep Sheep Diseases - immunology Sheep Diseases - prevention & control Sheep Diseases - virology Sheeppox virus Side effects vaccination vaccine development Vaccines Vaccines, Attenuated - adverse effects Vaccines, Attenuated - immunology Vaccines, Attenuated - therapeutic use Viral Vaccines - adverse effects Viral Vaccines - immunology Viral Vaccines - therapeutic use Viruses |
| title | classical live attenuated vaccine for sheep pox |
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