Chemistry of 2-vinylindoles: synthesis and applications

As a class of compounds, 2-vinylindoles have demonstrated a wide range of biological properties. These synthons have been studied extensively so far in the literature, a new divergent protocols for their chemical synthesis have been developed for biological investigations, or for their chemical application, especially their role in the total synthesis of natural products. In this review, methods for their synthesis using metal catalysis chemistry as a new avenue in green chemistry were also reported. In this review we shed the light of the chemistry of 2-vinylindoles, synthesis and application via metal coupling catalysis as a green approach.