Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance

Pre-targeting of bispecific antibodies is probed to enhance tumour retention while limiting clearance of administered multifunctional branched PEGylated nanomedicines. The temporal influence of pre-targeting on polymer interaction with tumour cells and tissue is explored using in vitro assays through to preclinical validation. A pre-targeting approach to preserve the stealth surface chemistry of PEGylated nanomedicines during circulation is demonstrated.