Evaluation of the efficacy of platelet-rich plasma (PRP) and injectable platelet-rich fibrin (i-PRF) in the acceleration of canine retraction: A randomized controlled trial

Aim: To compare the effectiveness of the intra-ligament injection of platelet-rich fibrin (i-PRF) and platelet-rich plasma (PRP) on canine movement rate during its orthodontic retraction. Materials and Methods: A randomized controlled trial with a split-mouth design included 40 patients (21.3 ± 1.8 years) whose all first premolars were indicated for extraction. Twenty patients were randomly allocated to each group (PRP vs. i-PRF). The Canine retraction was performed using Ricketts spring. PRP and i-PRF were injected twice in the intervention side with a 21-day interval. Saline was used likewise in the control side. Canine movement, rotation, and molar anchorage loss were measured on dental casts, whereas canine inclination was studied on cephalograms. Shapiro-Wilk normality test was performed, and a paired t-test was subsequently used for comparison within the same group. In addition, a two-sample t-test was used to compare the two groups. Results: A significantly higher rate of canine movement was observed in the PRP intervention group during the first month, unlike the i-PRF group in comparison with the control side. Besides, canine retracting rate was higher in the PRP group during the third month than in the i-PRF group. No statistical differences in canine inclination, rotation, and molar anchorage loss were found except for mandibular canine rotation in the PRP group and maxillary canine rotation between the two groups. Conclusion: PRP injection was probably better than the i-PRF in accelerating canine movement without avoiding the unwanted effects.