43-OR: Aqueous Retinol Binding Protein 3 Is Reduced in Patients with Advanced Diabetic Retinopathy in Type 1 and Type 2 Diabetes

The Joslin Medalist Study identified Retinol-binding protein 3 (RBP3) as a potential protective factor against diabetic retinopathy (DR) in the vitreous and retina of individuals with type 1 diabetes for 50 years or longer. This study evaluated the association of aqueous RBP3 concentration to vitreo...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2022-06, Vol.71 (Supplement_1)
Hauptverfasser:	CHOKSHI, TANVI, FICKWEILER, WARD, MITZNER, MARGALIT G., WU, I-HSIEN, BOUMENNA, TAHANI, ROBINSON, DEVON B., PARK, HYUNSEOK, PARK, KYOUNGMIN, AIELLO, LLOYD P., SUN, JENNIFER, KING, GEORGE L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cataracts Diabetes Diabetes mellitus (insulin dependent) Diabetes mellitus (non-insulin dependent) Diabetic retinopathy Epithelium Eye Patients Retina Retinal pigment epithelium Retinol-binding protein Retinopathy Vitamin A
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Zusammenfassung:	The Joslin Medalist Study identified Retinol-binding protein 3 (RBP3) as a potential protective factor against diabetic retinopathy (DR) in the vitreous and retina of individuals with type 1 diabetes for 50 years or longer. This study evaluated the association of aqueous RBP3 concentration to vitreous RBP3 concentrations and DR severity. We measured 131 aqueous samples from patients with type 1 and 2 diabetes undergoing cataract surgery at the Joslin Beetham Eye Institute (BEI) and postmortem samples of Medalists. Aqueous RBP3 concentrations in BEI and Medalists samples were similar for eyes with proliferative DR (PDR, P=0.11) and were well correlated between fellow eyes (r=0.65, P
ISSN:	0012-1797 1939-327X
DOI:	10.2337/db22-43-OR