1250-P: Identifying Pediatric A-ß+ Ketosis-Prone Diabetes (KPD)

1250-P: Identifying Pediatric A-ß+ Ketosis-Prone Diabetes (KPD)

KPD is characterized by diabetic ketoacidosis (DKA) in persons lacking the phenotype of autoimmune type 1 diabetes. The validated "Aβ" system classifies 4 KPD subgroups in adults, one of which (A-β+ KPD) is an atypical form that otherwise resembles type 2 diabetes (T2D) . Although recogniz...

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Veröffentlicht in:Diabetes (New York, N.Y.) N.Y.), 2022-06, Vol.71 (Supplement_1)
Hauptverfasser: KUBOTA-MISHRA, ELIZABETH A., HUANG, XIAOFAN C., MINARD, CHARLES G., ASTUDILLO, MARCELA, REFAEY, AHMAD K., MONTES, GRACIELA, SISLEY, STEPHANIE, BALASUBRAMANYAM, ASHOK, REDONDO, MARIA J., TOSUR, MUSTAFA
Format: Artikel
Sprache:eng
Schlagworte:
Autoantibodies
Children
Diabetes
Diabetes mellitus (insulin dependent)
Diabetes mellitus (non-insulin dependent)
Glucose
Insulin
Ketoacidosis
Pediatrics
Peptides
Phenotypes
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Zusammenfassung:KPD is characterized by diabetic ketoacidosis (DKA) in persons lacking the phenotype of autoimmune type 1 diabetes. The validated "Aβ" system classifies 4 KPD subgroups in adults, one of which (A-β+ KPD) is an atypical form that otherwise resembles type 2 diabetes (T2D) . Although recognized in children, better understanding of the prevalence and characteristics of pediatric A-β+ KPD is needed. The Rare and Atypical Diabetes Network (RADIANT) has modified the criteria for A-β+ KPD to: DKA within 6 months of diagnosis (dx) , not on SGLT2i, off insulin within 6 months of DKA with HbA1c
ISSN:0012-1797
1939-327X
DOI:10.2337/db22-1250-P