1174-P: A Posteriori Dietary Patterns and Insulin-Resistance Status and Diabetes Risk by Hispanic/Latino Heritage in HCHS/SOL

We examined links among dietary patterns (DPs) , insulin resistance (IR) , and diabetes risk by heritage (Cuban, Dominican, Mexican, Puerto Rican, and Central and South American) in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) . HCHS/SOL is a population-based cohort of 16,415 Hispanics/Latinos aged 18-74 y living in 4 US cities. At both visits, questionnaires and clinical examinations were administered, including two 24-hr diet recalls conducted at baseline only (2008-11) . Among 7,774 participants with 2nd-visit data (2014-17) and without diabetes at baseline, we performed heritage-specific principal factor analyses and characterized overarching DPs based on high-loading foods shared by ≥ 2 heritage groups. We classified 6-yr IR status (improved, unchanged, worsened) using a SD-change in fasting insulin. We defined incident diabetes using self-report, self-reported diabetes medication, or labs (fasting glucose (≥126 mg/dL) , post-OGTT (≥200 mg/dL) , or HbA1C (≥6.5%)) . We identified 5 overarching DPs: Burger, Fries, & Soft Drinks; White Rice, Beans, & Red Meats; Fish & Whole Grains; Cheese & Sweets; and Stew & Corn. Comparing highest to lowest quintiles, the Burger, Fries, & Soft Drinks DP in Dominicans (log-odds: 2.35, 95% CI: 1.02, 3.68, P trend=0.037) and White Rice, Beans, & Red Meats DP in Cubans (log-odds: 1.27, 95% CI: 0.49, 2.06, P trend =0.009) were associated with worsened (vs. unchanged) 6-year IR status. The Burger, Fries, & Soft Drinks DP in Puerto Ricans (OR: 3.00, 95% CI:1.50, 5.99, P trend=0.003) and the White Rice, Beans, & Red Meats DP in Central Americans (OR: 2.41, 95% CI: 1.05, 5.50, P trend=0.032) were associated with greater diabetes risk. In sum, dietary interventions for diabetes prevention should be tailored by Hispanic/Latino heritage.