57-OR: Responses to Lifestyle Intervention (LI) Are Associated to the Inter-Individual Variability in Glucose Metabolism at Baseline for Individuals at High Risk of Type 2 Diabetes (T2D)

LI can delay the onset of T2D. How inter-individual variability in response to LI relates to baseline phenotypic characteristics would help clinicians to advise on risk reduction. 328 subjects at high risk of T2D underwent a 12-weeks LI. Before and after LI, subjects were profiled for glucose and insulin measured through 75g-OGTT, peripheral (Matsuda (ISI) and HOMA) and hepatic (Hep-IR) insulin resistance indexes, insulinogenic index (IGI) , disposition index (DI=MI x dAUC0-180-Ins/glu) and target metabolomics. Hierarchical cluster analysis, based on indexes of insulin resistance (HOMA and ISI) and secretion (AUCins and IGI) , was performed to stratify the subjects at baseline. Pre vs. post values were compared in each cluster. Cluster analysis identified 4 groups with different degrees of glucose tolerance, insulin sensitivity and secretion (Figure A-D) , CL1 being the best. The 4 clusters showed different responses to LI: CL2-4 significantly improved insulin and reduced AUCins and α-ketoglutarate (p