32-OR: The Advancing Care for T1D Obesity Network (ACT1ON) Sequential Multiple Assignment Randomized Trial Pilot Re-randomization Results

32-OR: The Advancing Care for T1D Obesity Network (ACT1ON) Sequential Multiple Assignment Randomized Trial Pilot Re-randomization Results

Background: Sequential Multiple Assignment Randomized Trials (SMARTs) efficiently address practical treatment comparison questions and adapt dynamically based on response. They may be useful for development of approaches to co-manage weight and glycemia T1D, which is critical yet challenging. Method...

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Veröffentlicht in:Diabetes (New York, N.Y.) N.Y.), 2022-06, Vol.71 (Supplement_1)
Hauptverfasser: IGUDESMAN, DARIA, CRANDELL, JAMIE, POKAPRAKARN, TEERANAN, CORBIN, KAREN, ZAHARIEVA, DESSI P., ADDALA, ANANTA, THOMAS, JOAN, CASU, ANNA, RIDDELL, MICHAEL, PRATLEY, RICHARD E., KOSOROK, MICHAEL R., MAAHS, DAVID M., MAYER-DAVIS, ELIZABETH J.
Format: Artikel
Sprache:eng
Schlagworte:
Blood glucose
Body weight loss
Diabetes
Hypocaloric diet
Hypoglycemia
Nutrient deficiency
Obesity
Statistical analysis
Young adults
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Zusammenfassung:Background: Sequential Multiple Assignment Randomized Trials (SMARTs) efficiently address practical treatment comparison questions and adapt dynamically based on response. They may be useful for development of approaches to co-manage weight and glycemia T1D, which is critical yet challenging. Methods: Our SMART pilot with three diet periods enrolled young adults with T1D (BMI 27-39.9 kg/m²) . Participants were re-randomized after ∼3 months on the hypocaloric Look AHEAD (Low Fat) or Low Carbohydrate (Low Carb) ; or Mediterranean (Med, not calorie restricted) diet if
ISSN:0012-1797
1939-327X
DOI:10.2337/db22-32-OR