365-OR: Interruption of Glucagon Signaling Increases Delta-Cell Proliferation in Mouse and Human Islets

365-OR: Interruption of Glucagon Signaling Increases Delta-Cell Proliferation in Mouse and Human Islets

The determinants of delta cell mass are not known. As part of studies showing interruption of glucagon signaling (IGS) stimulates alpha cell proliferation in an amino acid (AA) -dependent manner, we noted an increase in delta cells. To investigate, we examined delta cell proliferation and mass in 3...

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Veröffentlicht in:Diabetes (New York, N.Y.) N.Y.), 2022-06, Vol.71 (Supplement_1)
Hauptverfasser: DAI, CHUNHUA, BRADLEY, AMBER, SPEARS, ERICK, SINGH, AJAY K., OLADIPUPO, FAVOUR O., JENKINS, REGINA, COATE, KATIE C., POWERS, ALVIN C.
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Animal models
Cell growth
Cell proliferation
Delta cells
Diabetes
Glucagon
Immunodeficiency
Immunoglobulin G
Kinases
Ribosomal protein S6
Signal transduction
TOR protein
Xenografts
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Zusammenfassung:The determinants of delta cell mass are not known. As part of studies showing interruption of glucagon signaling (IGS) stimulates alpha cell proliferation in an amino acid (AA) -dependent manner, we noted an increase in delta cells. To investigate, we examined delta cell proliferation and mass in 3 mouse models and a human islet xenograft model. Adult mice with deletion of glucagon (Gcg-/- ) had a 4.7-fold increase in Ki67-positive delta cells (1.50±0.14% vs. 0.32±0.12%, P
ISSN:0012-1797
1939-327X
DOI:10.2337/db22-365-OR