94-OR: CGM Metrics, HbA1c, and Retinopathy Are Differentially Associated by Disease Duration in Long-Duration Type 1 Diabetes

Continuous glucose monitor (CGM) -derived metrics provide measures of glycemic variability that are not captured with the use of HbA1c alone. However, they have not been evaluated in long-duration type 1 diabetes (T1D) subjects, in whom the greater risk of glycemic excursions and comorbidities highlight the need for other glycemic markers apart from HbA1c. Among the Joslin “Medalists” with T1D≥50 years, a single consecutive 14-day block of CGM data was remotely obtained from a subset of CGM users (n=64) after a period of routine activities. Using linear regression, mean historical HbA1c associated with mean glucose (β= 17.54, p