1092-P: Lipoprotein Insulin Resistance Index and Mortality in Heart Failure: A Population Study

Heart failure (HF) is associated with metabolic alterations, including insulin resistance (IR) . Perturbations in lipid metabolism and insulin signaling may impact outcomes, but the relationship between IR and mortality is not well characterized. The Lipoprotein Insulin Resistance Index (LPIR) is a...

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Veröffentlicht in:Diabetes (New York, N.Y.) N.Y.), 2022-06, Vol.71 (Supplement_1)
Hauptverfasser: TURECAMO, SARAH, WOLSKA, ANNA, OTVOS, JAMES D., REMALEY, ALAN, CONNERS, KATIE, JOO, JUNGNAM, PARK, HO YOUNG, SAMPSON, MAUREEN, BIELINSKI, SUZETTE J., SAUVER, JENNIFER ST, ROGER, VERONIQUE L.
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Sprache:eng
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Zusammenfassung:Heart failure (HF) is associated with metabolic alterations, including insulin resistance (IR) . Perturbations in lipid metabolism and insulin signaling may impact outcomes, but the relationship between IR and mortality is not well characterized. The Lipoprotein Insulin Resistance Index (LPIR) is a score (0-100; higher values signify greater IR) calculated from 6 lipoprotein subclass/size parameters measured by nuclear magnetic resonance (NMR) . We examined the association between LPIR and death in a HF community cohort. LPIR was measured by NMR LipoProfile®. Meta-Analysis Global Group in Chronic HF (MAGGIC) scores were calculated from clinical data. Kaplan-Meier curves were used to evaluate survival; Cox regression was used to estimate risk of death by LPIR quartile. Among 1,381 community-dwelling persons with HF, the median LPIR score was 38 (IQR 21-56) . Higher LPIR was associated with younger age, diabetes, smoking, obesity, and lower MAGGIC scores, but not ejection fraction. Survival increased by LPIR quartile (p
ISSN:0012-1797
1939-327X
DOI:10.2337/db22-1092-P