81-OR: High Throughput Proteomics Identifies Neurofilament Light Chain (NFL) as a Novel Blood Biomarker for Detection of Diabetic Sensorimotor Polyneuropathy

Background: The neurofilament light chain (NFL) is a polypeptide abundant in neuronal axons, reflecting ongoing neuroaxonal degeneration when detected in the blood. However, no previous study has explored NFL as a potential biomarker for diabetic sensorimotor polyneuropathy (DSPN) , a neurodegenerat...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2022-06, Vol.71 (Supplement_1)
Hauptverfasser:	MAALMI, HAIFA, STROM, ALEXANDER, HAUCK, STEFANIE M., ZAHARIA, OANA P., STRASSBURGER, KLAUS, BÖNHOF, GIDON J., RATHMANN, WOLFGANG, TRENKAMP, SANDRA, BURKART, VOLKER, SZENDROEDI, JULIA M., ZIEGLER, DAN, RODEN, MICHAEL, HERDER, CHRISTIAN
Format:	Artikel
Sprache:	eng
Schlagworte:	Axons Biomarkers Cardiovascular diseases Cholesterol Diabetes Diabetes mellitus Epidermal growth factor receptors Nerve conduction Nervous system Neurodegeneration Neurodegenerative diseases Nonsteroidal anti-inflammatory drugs Polyneuropathy Proteomics Sensorimotor system Sensory neurons Serum levels
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Zusammenfassung:	Background: The neurofilament light chain (NFL) is a polypeptide abundant in neuronal axons, reflecting ongoing neuroaxonal degeneration when detected in the blood. However, no previous study has explored NFL as a potential biomarker for diabetic sensorimotor polyneuropathy (DSPN) , a neurodegenerative disease of the peripheral nervous system commonly found in individuals with diabetes. We hypothesized that higher serum NFL levels are associated with DSPN. Methods: We used data from the German Diabetes Study, a prospective observational study that includes adults with recent-onset diabetes (
ISSN:	0012-1797 1939-327X
DOI:	10.2337/db22-81-OR