Plasma‐coated PCL scaffolds with immobilized platelet‐rich plasma enhance the wound healing in diabetics mice

COOH plasma polymer layers deposited onto polycaprolactone (PCL) nanofibers by plasma polymerization of CO2 and C2H4 in the Ar atmosphere were obtained and tested for diabetic wound healing. Simply by changing the deposition time, very different morphologies of coated PCL nanofibers were achieved. In vivo tests revealed that by applying modified nanofibers for 10 days, wound healing accelerated by 32.1%. Compared to a controlled wound characterized by an acute inflammatory process, wounds covered with nanofibers with platelet‐rich plasma demonstrated complete healing with a high percentage of collagen fibers on Day 19. The synthesis of novel and efficient wound dressing requires significant efforts and the treatment of diabetic ulcers is a critical issue for the 21st century. Our research is focused on careful investigation of the plasma deposition of the COOH layers onto polycaprolactone nanofibers and further analyses in vitro and in vivo for the healing of type 2 diabetic wounds. Our first results show the high potential of biodegradable plasma‐modified nanofibers to solve this highly challenging task.