Synthesis of Ethyl Ethers 13,14-Dehydro-16-aryloxy-11-deoxyprostaglandin E1

Synthesis of Ethyl Ethers 13,14-Dehydro-16-aryloxy-11-deoxyprostaglandin E1

Conjugated 1,4-addition of cuprate reagents, prepared from trimethylsilyl ethers of 3-hydroxy-4-aryloxybut-1-ynes, to 2-[6-(ethoxycarbonyl)hexyl]cyclopent-2-en-1-one resulted in the preparation of 13,14-dehydro-16-aryloxy-11-deoxyprostaglandins E 1 as mixtures of the 8,12- cis/trans isomers.

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Veröffentlicht in:Russian journal of organic chemistry 2022, Vol.58 (5), p.691-696
Hauptverfasser: Ivanova, N. A., Shavaleeva, G. A., Miftakhov, M. S.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Ethers
Organic Chemistry
Reagents
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Zusammenfassung:Conjugated 1,4-addition of cuprate reagents, prepared from trimethylsilyl ethers of 3-hydroxy-4-aryloxybut-1-ynes, to 2-[6-(ethoxycarbonyl)hexyl]cyclopent-2-en-1-one resulted in the preparation of 13,14-dehydro-16-aryloxy-11-deoxyprostaglandins E 1 as mixtures of the 8,12- cis/trans isomers.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428022050086