New Synthesis of Tetrahydroisoquinolines

New Synthesis of Tetrahydroisoquinolines

The reaction of cyclohexylidenecyanothioacetamide with N , N -dimethylformamide dimethyl acetal was studied. This transformation, depending on the reaction conditions, leads to different results: when the starting reagents are refluxed without a solvent, 3-(methylsulfanyl)-5,6,7,8-tetrahydroisoquino...

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Veröffentlicht in:Russian journal of organic chemistry 2022-05, Vol.58 (5), p.657-662
Hauptverfasser: Dyachenko, I. V., Dyachenko, V. D., Dorovatovskii, P. V., Khrustalev, V. N., Nenajdenko, V. G.
Format: Artikel
Sprache:eng
Schlagworte:
Benzene
Chemical synthesis
Chemistry
Chemistry and Materials Science
Dimethyl acetals
Dimethylformamide
Organic Chemistry
Reagents
Refluxing
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Beschreibung
Zusammenfassung:The reaction of cyclohexylidenecyanothioacetamide with N , N -dimethylformamide dimethyl acetal was studied. This transformation, depending on the reaction conditions, leads to different results: when the starting reagents are refluxed without a solvent, 3-(methylsulfanyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile is formed, and refluxing in benzene leads to 2-cyano-3-(dimethylamino)prop-2-enethioamide. The structure of these products was studied by XRD analysts.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428022050037