Synthesis, Computational Insights, and Anticancer Activity of Novel Indole–Schiff Base Derivatives

Synthetic and naturally available compounds with indole moiety are known to show significant biological activity. This paper describes computational insights and synthesis of novel indole clubbed Schiff base derivatives ( IVa – j ) with improved biological profile. Synthesized molecules were characterized by 1 H NMR and 13 C NMR spectroscopy. The prepared derivatives were evaluated for their in vitro anticancer activity against A549 cell line using MTT assay. Results revealed significant potential of the synthesized compounds, especially ( IVb ), which exhibited high anticancer activity.