Socio-demographic and psychometric aspects and baseline inflammatory markers in depressed patients with coronary artery disease – Add-on analysis of the multicentre SPIRR-CAD trial

Objective Inflammation is considered as an important mediator for the relationship between depression and coronary artery disease (CAD). Inflammatory markers are linked to mental conditions and have a causal role in the development of arteriosclerosis. The aim of this analysis is to investigate the interplay between socio-demographic and psychological factors, as well as the inflammatory'markers myeloperoxidase (MPO), leptin and adiponectin in depressed patients with CAD. Methods Baseline data collection relies on data from the SPIRR-CAD trial, a prospective, multicenter, randomized, controlled psychotherapy study. 553 depressed CAD patients (437 male, 116 female; mean age 59.1 ± 9.5) provided socio-demographic information (age, sex), psychometric data (HADS. HAM-D, DS14. SF36). and levels of inflammatory markers MPO, leptin and adiponectin. Results First analysis revealed higher adiponectin levels in older (p = 0.002) and female (p< 0.001) participants, whereas a type-D personality was associated with lower adiponectin levels (p< 0.001). Women showed significantly higher leptin levels than men (p < 0.001). A lower physical quality of life was also correlated with higher leptin levels (p < 0.001). Increased MPO levels could be found in patients with higher depression levels (p = 0.028). Detailed results will be presented at the conference. Conclusions The current analysis of socio-demographic, psychometric and inflammatory parameters revealed encouraging correlations in the context of CAD. Higher adiponectin levels were associated with older age, female sex and the absence of a type-D personality. Higher leptin levels were associated with female sex and a lower physical quality of life. Nevertheless, clinical significance and interpretation of these results need to be further investigated.