Synthesis of Tetrahydro‐4H‐pyridoisoquinolin‐4‐ones from Ugi 4‐CR‐Derived Dihydroisoquinoline‐Xanthates
An efficient protocol for the synthesis of poly‐functionalized 1,2,3,6‐tetrahydro‐4H‐pyrido[1,2‐b]isoquinolin‐4‐ones is described. First, propargyl‐containing Ugi adducts were transformed to polysubstituted dihydroisoquinolines by an intramolecular Au‐catalyzed alkyne hydro‐arylation, followed by th...
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Veröffentlicht in: | European journal of organic chemistry 2022-06, Vol.2022 (22) |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | An efficient protocol for the synthesis of poly‐functionalized 1,2,3,6‐tetrahydro‐4H‐pyrido[1,2‐b]isoquinolin‐4‐ones is described. First, propargyl‐containing Ugi adducts were transformed to polysubstituted dihydroisoquinolines by an intramolecular Au‐catalyzed alkyne hydro‐arylation, followed by the alkene isomerization process. Then, these pivotal intermediates were engaged in a xanthate‐based oxidative radical cascade addition/cyclization process with a suitable alkene. |
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ISSN: | 1434-193X 1099-0690 |
DOI: | 10.1002/ejoc.202200080 |