Anodic dearomatization of 2-alkynylanilines for the synthesis of multi-functionalized indoles

An anodic oxidative dearomatization reaction of 2-alkynylanilines was developed. The formed dearomatized compounds were used as versatile precursors in the synthesis of a variety of benzenoid ring multi-functionalized indoles through simple conversions. An anodic oxidative dearomatization of 2-alkyn...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2022-06, Vol.58 (48), p.6797-68
Hauptverfasser: Chen, Zhuowen, He, Qiuqin, Guo, Hao, Fan, Renhua
Format: Artikel
Sprache:eng
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Zusammenfassung:An anodic oxidative dearomatization reaction of 2-alkynylanilines was developed. The formed dearomatized compounds were used as versatile precursors in the synthesis of a variety of benzenoid ring multi-functionalized indoles through simple conversions. An anodic oxidative dearomatization of 2-alkynylaniline and its application for the synthesis of benzenoid ring multi-functionalized indoles is reported.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc01766k