Hypercoagulability, endotheliopathy, and inflammation approximating 1year after recovery: Assessing the long‐term outcomes in COVID‐19 patients

Sustained hypercoagulability and endotheliopathy are present in convalescent COVID‐19 patients for up to 4 months from recovery. The hemostatic, endothelial, and inflammatory profiles of 39 recovered COVID‐19 patients were evaluated up to 16 months after recovery from COVID‐19. These values were com...

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Veröffentlicht in:American journal of hematology 2022-07, Vol.97 (7), p.915-923
Hauptverfasser: Fan, Bingwen Eugene, Wong, Shiun Woei, Christina Lai Lin Sum, Lim, Gek Hsiang, Leung, Bernard PuiLam, Chuen Wen Tan, Ramanathan, Kollengode, Rinkoo Dalan, Cheung, Christine, Xin Rong Lim, Mucheli Shravan Sadasiv, David Chien Lye, Young, Barnaby Edward, Yap, Eng Soo, Chia, Yew Woon
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Sprache:eng
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Zusammenfassung:Sustained hypercoagulability and endotheliopathy are present in convalescent COVID‐19 patients for up to 4 months from recovery. The hemostatic, endothelial, and inflammatory profiles of 39 recovered COVID‐19 patients were evaluated up to 16 months after recovery from COVID‐19. These values were compared with a control group of healthy volunteers (n = 124). 39 patients (71.8% males, median age 43 years) were reviewed at a mean of 12.7 ± 3.6 months following recovery. One patient without cardiovascular risk factors had post COVID‐19 acute ischaemic limb. Elevated D‐dimer and Factor VIII levels above normal ranges were noted in 17.9% (7/39) and 48.7% (19/39) of patients respectively, with a higher median D‐dimer 0.34 FEU μg/mL (IQR 0.28, 0.46) (p 
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.26575