A novel near-infrared fluorescent probe for the detection of sulfur dioxide derivatives and its application in biological imaging

SO 2 plays an important role in our life and is also associated with many diseases, so it is a double-edged sword. Therefore, it is necessary to develop a probe for detecting sulfur dioxide derivatives. Herein, on account of the Michael addition reaction mechanism, a near-infrared (NIR) fluorescent probe, HBQI, toward sulfur dioxide derivatives was developed, and the probe has high selectivity and strong anti-interference ability. The application study indicates that probe HBQI can detect sulfur dioxide derivatives in real water samples with good recovery. In addition, HBQI has been applied to live-cell imaging through confocal fluorescence techniques. HBQI can effectively detect HSO 3 − and has good photostability, selectivity and anti-interference ability. The reaction was completed in about 1 min.