Additive antiproteinuric effect of pentoxifylline in patients with diabetic nephropathy under angiotensin receptor blockade: A short-term, randomized, and controlled trial

Aims and Objectives: The aims of this study were to study the safety and efficacy of pentoxifylline added on to an angiotensin II receptor blocker (ARB) to reduce the progression of the disease condition in diabetic nephropathy (DN) patients over 1 year. Diabetic Nephropathy; Pentoxifylline; Urine A...

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Veröffentlicht in:National journal of physiology, pharmacy and pharmacology pharmacy and pharmacology, 2022, Vol.12 (6), p.1-827
Hauptverfasser: Thottol, Reema, George, Ancy, G, Laxmi
Format: Artikel
Sprache:eng
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Zusammenfassung:Aims and Objectives: The aims of this study were to study the safety and efficacy of pentoxifylline added on to an angiotensin II receptor blocker (ARB) to reduce the progression of the disease condition in diabetic nephropathy (DN) patients over 1 year. Diabetic Nephropathy; Pentoxifylline; Urine Albumin/Creatinine Ratio; Urine Tumor Necrosis Factor-a INTRODUCTION Diabetes mellitus (DM) is a chronic metabolic disorder which is characterized by hyperglycemia. [...]of this, ANP gets released from cardiac myocytes which induce natriuresis causing afferent arteriolar dilatation and an increase in intraglomerular pressure - the pathogenesis of DN. The cells of the endothelium, mesangium, glomerulus, and tubular epithelial cells are able to produce cytokines. [...]the experimental works have shown that renal mRNA levels for TNF-alpha are significantly increased in diabetic rats when compared with normal rats.
ISSN:2320-4672
2231-3206
DOI:10.5455/njppp.2022.12.04159202221042022