Transition Metal Catalyzed Enantioselective Migratory Functionalization Reactions of Alkenes through Chain‐Walking

Comprehensive Summary “Chain‐walking” reactions could realize to modify a molecule at the position far away from the active site. It has been a hot topic in the research field of organic synthesis. As a number of achievements have been made by researchers, the products of transition metal‐catalyzed chain‐walking reactions could be obtained with good enantioselectivity. This review summarized the researches on the asymmetric chain‐walking reactions catalyzed by transition metal in the past decade. These works are classified according to the species of metal catalysts. “Chain‐walking” reactions, which could realize constructing chiral center at the position far away from the active site, have been summarized according to the species of metal catalysts. This review highlighted the scope and mechanism, as well as the applications of these reactions.